Results 61 to 70 of about 2,710 (264)

Modeling and Analysis of Transmission Efficiency for 3K Planetary Gearbox with Flexure-Based Carrier for Backdrivable Robot Joints

open access: yesActuators
A high-gear-ratio anti-backlash 3K planetary gearbox with a preloaded flexure-based carrier is a suitable reducer for robot joints owning to its compact design and high transmission accuracy.
Qinghao Du   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Influence of seismic loading on axial load variation in reinforced concrete columns [PDF]

open access: yese-GFOS, 2018
Experimental tests demonstrated the importance of the axial load variation in the seismic response of RC columns, namely, through the reduction in the strength capacity, reduced deformation capacity, and reduced energy dissipation capacity.
Hugo Rodrigues   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Investigating the Mechanism of Shear Fatigue in Reinforced Concrete Beams subjected to Pulsating and Moving Loads using Digital Image Correlation

open access: yesMATEC Web of Conferences, 2019
An experimental investigation on three shear-critical reinforced concrete beams was performed to investigate the mechanism of shear fatigue. The first beam was simply tested to failure under monotonic loading to determine the static capacity, whereas the
Suryanto Benny   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Improving Support Stiffness of Flexure Mechanisms by Statically Balancing

open access: yes, 2021
Static balance eliminates the actuation stiffness of flexure mechanisms and thereby reduces the motor effort and unwanted heat production. However, this typically comes at the cost of lowered support stiffness and stroke. This paper aims to show that the maximum stresses in the flexures may be reduced as well by static balance.
de Jong, Jan   +3 more
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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