Results 71 to 80 of about 3,634 (300)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
ActuatorsA high-gear-ratio anti-backlash 3K planetary gearbox with a preloaded flexure-based carrier is a suitable reducer for robot joints owning to its compact design and high transmission accuracy.
Qinghao Du +4 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Evaluation of Stiffness and Parametric Modelling of XY Flexure Mechanism for Precision Applications
, 2018 In miniaturized scale electro-mechanical framework (MEMS) flexural instruments are generally utilized in light of their preferences, frictionless and wear less movement and high accuracy. Flexures rely upon material versatility for their usefulness.
Deshmukh, Suhas P +5 more
core +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Influence of seismic loading on axial load variation in reinforced concrete columns [PDF]
e-GFOS, 2018 Experimental tests demonstrated the importance of the axial load variation in the seismic response of RC columns, namely, through the reduction in the strength capacity, reduced deformation capacity, and reduced energy dissipation capacity.
Hugo Rodrigues +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Development and implementation of a deflection amplification mechanism for capacitive accelerometers
, 2012 Micro-Electro-Mechanical-Systems (MEMS) and especially physical sensors are part of a flourishing market ranging from consumer electronics to space applications.
Zeimpekis, Ioannis
core
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
MATEC Web of Conferences, 2019 An experimental investigation on three shear-critical reinforced concrete beams was performed to investigate the mechanism of shear fatigue. The first beam was simply tested to failure under monotonic loading to determine the static capacity, whereas the
Suryanto Benny +6 more
doaj +1 more source