Results 71 to 80 of about 2,710 (264)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The Geomechanics of the Dangkhar Landslide, Himachal Pradesh, India

Geotechnics
The Dangkhar Landslide is an extremely large landslide located in the Spiti Valley of Himachal Pradesh, India. The landslide is situated in a remote high mountain desert within the Tethys Himalaya at elevations between 3400 m and 5600 m.
Markus Kaspar, D. Scott Kieffer
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Behavior of high performance artificial lightweight aggregate concrete reinforced with hybrid fibers

MATEC Web of Conferences, 2018
In this investigation, sustainable High Performance Lightweight Aggregate Concrete (HPLWAC) containing artificial aggregate as coarse lightweight aggregate (LWA) and reinforced with mono fiber, double and triple hybrid fibers in different types and ...
Khalil Wasan, Ahmed Hisham, Hussein Zainab   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Fabrication of green anti-microbial and anti-static cement building bricks

Scientific Reports
The design cement mix of grade 350 was created in accordance with Egyptian Standards by partially substituting the fine aggregate with WPVC waste in various weight percentages (10, 20, 30, 40, 50, 75, and 100%). A control mix with 0% replacement was also
Abeer Reffaee, Mona Saied, Shimaa Farag hamieda, Sh. K. Amin   +3 more
doaj   +1 more source

Flexural Behavior of Hybrid-Reinforced Concrete Exterior Beam-Column Joints under Static and Cyclic Loads

Fibers, 2019
This study presents an experimental investigation of the flexure behavior of exterior beam-column joints made from hybrid concrete (normal concrete (NC) and reactive powder concrete (RPC)) or hybrid reinforcement (steel and carbon fiber reinforced ...
Ammar Yaser Ali, Ali Abdulameer Al-Rammahi   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source