Results 81 to 90 of about 3,634 (300)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Determination of Young's modulus for spruce, fir and isotropic materials by the resonance flexure method with comparisons to static flexure and other dynamic methods

, 1996
Summary Dynamic methods provide rapid and accurate means to determine Young's modulus, i.e. the modulus of elasticity, of wood. For dry, clear specimens of ~picba commun (Norway spruce, picea excelsa) and sapin pictin~ (silver fir, abies amabilis ...
D W Haines, C Herbe, J M Leban
core  

Experimental analysis of dynamic effects of FRP reinforced masonry vaults

, 2015
An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults.
Kathryn Coventry, Antonio Borri, Borri, Antonio, Coventry, Kathryn, Giulio Castori, Castori, Giulio, Marco Corradi, Corradi, Marco   +7 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Geomechanics of the Dangkhar Landslide, Himachal Pradesh, India

Geotechnics
The Dangkhar Landslide is an extremely large landslide located in the Spiti Valley of Himachal Pradesh, India. The landslide is situated in a remote high mountain desert within the Tethys Himalaya at elevations between 3400 m and 5600 m.
Markus Kaspar, D. Scott Kieffer
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Flexure Guided Planar Scanner for Scanning Probe Microscope; Part2: Evaluation of Static and Dynamic Properties

, 2005
this paper shows experimental evaluation results of the nano-positioning planner scanner used in the scanning probe microscope. The planar scanner is composed of flexure guides, piezoelectric actuators and feedback sensors as the static properties of the
Lee, Moo Yeon, Gweon, Dea Gab, Lee, Dong Yeon   +2 more
core   +1 more source

Thermo-Elastic Design of Flexure for Spaceborn Opto-Mechanical Payloads

, 2011
Spaceborn optical payload consists of optical elements supported by mechanical structure in desired orientation. Mechanical structure made up of various dissimilar materials like aluminum & invar possess dissimilar thermo-elastic behavior.
Naimesh Patel, C.P. Dewan, D. Subrahmanyam, J.B. Rami, A.P. Vora   +4 more
core   +1 more source