Results 121 to 130 of about 4,038,016 (323)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Shielding weakening of high-velocity fluid against precipitation-static

open access: yesEngineering Applications of Computational Fluid Mechanics
Recent experiments have demonstrated that high-density space charge around a structure can shield precipitation-static on the structure’s surface, while high-velocity fluid can weaken this shielding effect.
Fusheng Wang   +10 more
doaj   +1 more source

Student Worksheet Static Fluid Material Based on Scientific Approach Using Giuded Inquiry Model

open access: yes, 2017
This Research and development goal is to produce Student Worksheet (SWS) static fluid material based on the scientific approach using guided inquiry learning model, which is easy, interesting, useful and effective.
Supardi Supardi   +2 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental and numerical study on the drainage performance and fluid flow of Venturi tubes

open access: yesAIP Advances, 2019
Venturi tubes have been widely applied to the mixture and drainage of fluid due to the Venturi effect. In this work, an experimental investigation and a numerical simulation are conducted to analyze the fluid flow processing and drainage performance of ...
Junxia Zhang   +3 more
doaj   +1 more source

Understanding students' concepts through guided inquiry learning and free modified inquiry on static fluid material

open access: yes, 2017
This study provides information on understanding students' concepts in guided inquiry learning groups and in free modified inquiry learning groups. Understanding of student concept is reviewed on the concept of static fluid case.
Sularso Sularso, W. Sunarno, S. Sarwanto
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Multiple-orifice throttle valve [PDF]

open access: yes, 1969
Multiple-orifice throttle valve is not subject to cold welding in a vacuum environment and is compatible with strong oxidizing fluid. The valve is of all metal construction using simple components that do not slide or rotate and excludes static or ...
Fitton, J. S., Jr., Rosales, L. A.
core   +1 more source

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