Results 41 to 50 of about 28,990 (256)

Investigating the Friction Behavior of Turn-Milled High Friction Surface Microstructures under Different Tribological Influence Factors

open access: yesJournal of Manufacturing and Materials Processing, 2022
The coefficient of friction (COF) is an important parameter for mechanical engineers to consider when designing frictional connections. Previous work has shown that a surface microstructuring of the harder friction partner leads to a significant increase
Jonathan Schanner   +3 more
doaj   +1 more source

Static Friction Coefficient Is Not a Material Constant [PDF]

open access: yesPhysical Review Letters, 2011
The static friction coefficient between two materials is considered to be a material constant. We present experiments demonstrating that the ratio of shear to normal force needed to move contacting bodies can, instead, vary systematically with controllable changes in the external loading configuration.
Oded, Ben-David, Jay, Fineberg
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

TRIBOELECTRIFICATION OF POLYMERIC TEXTILES [PDF]

open access: yesJournal of the Egyptian Society of Tribology, 2015
The present work investigates the possibility of having minimum electric static charge generated from the friction between the proposed polymeric composites consisting of polytetrafluoroethylene, (PTFE) and polyamide, (PA) fibres when sliding against ...
Y. AlEili, M. K. Mohamed, W. Y. Ali
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Effects of deep friction massage and static stretching in non-specific neck pain

open access: yesMedical Journal of Dr. D.Y. Patil Vidyapeeth, 2019
Introduction: Neck pain is a frequent complaint of the era. The muscles around the neck tend to get shorter, leading to restricted neck mobility.
Madiha Yasin   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

STATIC FRICTION COEFFICIENT MODEL OF JOINT SURFACES CONSIDERING ASPERITIES INTERACTION AND SUBSTRATE DEFORMATION (MT)

open access: yesJixie qiangdu, 2023
A statistical model of static friction factor of joint surfaces was deduced, which was more in line with the actual situation and takes into account the interaction of asperities and the deformation of the substrate.
XU YongTai, ZHANG XueLiang, ZHAO HaiLu
doaj  

Subloading-overstress friction model

open access: yesNihon Kikai Gakkai ronbunshu, 2014
The subloading-friction model proposed formerly is capable of describing the transition from the static to the kinetic friction and the recovery of static friction, which leads to the negative rate-sensitivity, i.e.
Koichi HASHIGUCHI   +4 more
doaj   +1 more source

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