Results 111 to 120 of about 1,093,881 (295)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Quasi-Static Voltage Scaling for Energy Minimization with Time Constraints

, 2005
Supply voltage scaling and adaptive body-biasing are important tech-niques that help to reduce the energy dissipation of embedded systems. This is achieved by dynamically adjusting the voltage and performance settings according to the application needs ...
Eles, Petru, Peng, Zebo, Al-Hashimi, Bashir M, Marcus T. Schmitz, Bashir M. Al Hashimi, Schmitz, Marcus T, Zebo Peng, Andrei, Alexandru, Alexandru Andrei, Petru Eles   +9 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Application-oriented resource matching model based on trust for internet-based virtual computing environment

Tongxin xuebao, 2013
In order to solve the problem of reasonable resource s ing in the virtual computing environment (iVCE),a resource matching model,based on trust “resource sliding window” model,was proposed.Firstly,the resources were classified in advance by their static ...
Chun-ge ZHU, Xin-ran LIU, Yi-xian YANG, Hong ZHANG   +3 more
doaj   +2 more sources

An optimized two‐phase demand‐responsive transit scheduling model considering dynamic demand

IET Intelligent Transport Systems
Demand‐responsive transit has gradually attracted attention in recent years for its flexibility, efficiency, and ability to meet the diverse travel demands of passengers.
Cui‐Ying Song, He‐Ling Wang, Lu Chen, Xue‐Qin Niu   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Research Review on Workshop Scheduling for Intelligent Manufacturing: Digital Twin Modeling, Optimization Algorithm, and System Architecture

Machines
Digital twin, as a new generation of industrial intelligent technology, has become a key technology for achieving virtual-physical interaction and real-time optimization in intelligent manufacturing systems due to its capability for high-fidelity virtual
Adilanmu Sitahong, Yulong Chen, Yiping Yuan, Areziguli Wubuli, Junyan Ma, Peiyin Mo   +5 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Static Scheduling Strategies for Heterogeneous Systems [PDF]

, 2012
In this paper, we consider static scheduling techniques for heterogeneous systems, such as clusters and grids. We successively deal with minimum makespan scheduling, divisible load scheduling and steady-state scheduling.
Legrand, Arnaud, Robert, Yves, Beaumont, Olivier   +2 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source