Results 51 to 60 of about 47,042 (296)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The Effect of Muscle Energy Technique on Hamstring Extensibility: The Mechanism of Altered Flexibility [PDF]

, 2003
Purpose: To investigate the effectiveness of muscle energy technique in increasing passive knee extension and to explore the mechanism behind any observed change.\ud Procedure: 40 asymptomatic subjects were randomly allocated to control or experimental ...
Fryer, Gary, Ballantyne, Fiona, McLaughlin, Patrick   +2 more
core   +1 more source

Immediate Effects of Combined Stretching Protocols on Scapular Myoelectric Activity and Kinematics in Gymnasts [PDF]

Journal of Rehabilitation Sciences and Research
Background: Stretching is widely used to improve joint range of motion (ROM). This study examined the immediate effects of different stretching protocols on scapular muscle activity and motion in elite gymnasts.
omid kazemi, Paulo Marchetti, Aboozar Saadatian, Hadi Abbaszade ghanati   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The acute time course of muscle and tendon tissue changes following one minute of static stretching

Current Issues in Sport Science, 2020
The purpose of this study was to investigate the time course of the changes of various muscle and tendon mechanical properties and the function responses of the plantar flexor muscles following 1 min of static stretching.
Andreas Konrad, Markus Tilp
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Acute and Chronic Effects of Static Stretching on Neuromuscular Properties: A Meta-Analytical Review

Applied Sciences, 2023
The aim of this review was to provide an overview of the recent findings on the acute and chronic effects of static stretching on joint behaviors and neuromuscular responses and to discuss the overall effects of acute and chronic static stretching on ...
Ruchi Shah, Marina W. Samuel, Jongsang Son   +2 more
doaj   +1 more source

A Comparison of Static Stretching Versus Combined Static and Ballistic Stretching in Active Knee Range of Motion

Internet Journal of Allied Health Sciences and Practice, 2015
Background: There is continued controversy related to flexibility gains from different stretching protocols and within single protocols. Stretching methods include static, ballistic, dynamic, and proprioceptive neuromuscular facilitation (PNF). A combination of stretching methods may be an improved way to increase active knee range of motion (ROM ...
Nathan Blackhurst, James Peterson, Valerie Herzog, Ericka Zimmerman   +3 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The optimal duration of high-intensity static stretching in hamstrings

PLoS ONE, 2020
Objectives The purpose of this study was to compare the duration of high-intensity static stretching on flexibility and strength in the hamstrings. Methods Fourteen healthy males (20.8 ± 0.6 years, 170.7 ± 6.5 cm, 66.4 ± 9.9 kg) underwent high-intensity ...
Kosuke Takeuchi, Masatoshi Nakamura, Andrew Philip Lavender   +2 more
doaj   +2 more sources