Results 151 to 160 of about 140,911 (217)

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

open access: yesCancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah   +3 more
wiley   +1 more source

Long‐term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Introduction Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder associated with an increased risk of cutaneous tumors. Objectives To develop a feasible and easy‐to‐apply treatment regimen for long‐time disease control of DSAP including prevention of new skin tumors. Patients and Methods 19 patients with DSAP
Berenice M. Lang   +6 more
wiley   +1 more source

Risk of progression to type 2 diabetes or regression to normoglycaemia among Ghanaians with prediabetes living in Ghana and the Netherlands: The RODAM prospective study

open access: yesDiabetic Medicine, EarlyView.
Abstract Introduction Evidence shows that ethnicity affects the risk of progression of prediabetes to type 2 diabetes(T2D) or regression to normoglycaemia However, little is known about progression rates among sub‐Saharan African populations or whether geographical context affects risk variations.
Emmanuel Bannerman‐Williams   +8 more
wiley   +1 more source

The burden of diabetic foot ulcers in a multi‐ethnic Asian cohort

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Diabetic foot ulcers (DFUs) are a major source of morbidity among individuals with diabetes mellitus (DM), imposing a substantial burden on healthcare systems. Our institution established a multidisciplinary service aiming to facilitate early specialist intervention for DFU management.
Zongwen Wee   +2 more
wiley   +1 more source

Underdiagnosed and Undertreated: Obesity and Its Cardiometabolic Burden in Swedish Clinical Practice—Insights From the AROS Database

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To quantify real‐world diagnosis and treatment of obesity in Sweden, describe cardiometabolic comorbidity burden across obesity classes, and compare long‐term cardiovascular outcomes with the general population. Materials and Methods This population‐based cohort study used the AROS (Analysis of Real‐world data of patients with Obesity in ...
Viveca Ritsinger   +6 more
wiley   +1 more source

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