Results 81 to 90 of about 226,308 (303)

Intensive versus standard dose statin therapy: the costs and benefits for patients with acute coronary syndrome [PDF]

Introduction: Recent NICE guidance in England and Wales states that statin therapy for secondary CVD should "usually be initiated with a drug with a low acquisition cost (taking into account required daily dose and product price per dose)".
Ara, R., Hall, A.S., Pandor, A., Ward, S.   +3 more
core   +3 more sources

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials [PDF]

, 2012
Background - It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins.
,, Delhaas, T., Elders, J., Frueh, M., Hiippala, A., Janousek, J., Krupickova, S., Prinzen, F. W., Rosenthal, E., Tomaske, M., Van Geldorp, I.   +10 more
core   +6 more sources

"STATINS KALEIDOSCOPE". MYOPATHY FROM STATINS

, 2019
Statins are medications that inhibit the 3-hydroxy-3-methylglutaryl-CoA reductase enzyme, thus inhibiting cholesterol biosynthesis. Statins reduce cardiovascular risk and morbidity in patients with coronaropathia, however, without forgetting their side effect in muscle toxicity. Clinically, patients with myopathy caused by statins are divided into four
ERVIN RAPUSHI, TEUTA BRACKA, ARTUR ZOTO, LEDIANA NUHAJ, INDIN XHEMALI   +4 more
openaire   +1 more source

Assessment of Initial Stay Time and Work‐Rest Scheduling Over Consecutive Moderate‐Intensity Workdays in Hot Environments in Young and Older Males and Females

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction Initial stay time (IST), the duration of continuous work before core temperature reaches 38.0°C, has been characterized in young and older adults but not across consecutive work periods or in conjunction with standard work‐rest cycles.
Glen P. Kenny, Katie E. Wagar, Roberto C. Harris‐Mostert, Kristina‐Marie T. Janetos, James J. McCormick, Kelli E. King, Leonidas G. Ioannou, Ronald J. Sigal, W. Shane Journeay, Fergus K. O'Connor   +9 more
wiley   +1 more source

Statin adherence is lower in primary than secondary prevention: A national follow-up study of new users.

PLoS ONE, 2020
BackgroundMaintaining adherence to statins reduces the risk of an initial cardiovascular disease (CVD) event in high-risk individuals (primary prevention) and additional CVD events following the first event (secondary prevention).
Finn Sigglekow, Simon Horsburgh, Lianne Parkin   +2 more
doaj   +1 more source

SAFETY EVALUATION OF STATIN IN YOGYAKARTA, INDONESIA [PDF]

, 2009
Background : The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-Co-A) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum Low-Density Lipoprotein cholesterol (LDL-c)concentrations.
Anni, Anni, Labado, R.O., Perwitasari, Dyah Aryani, Udu, W.S.A.   +3 more
core  

Statin use and survival in resectable pancreatic cancer: confounders and mechanisms. [PDF]

, 2016
A first point regards the possible activity of drugs other than statins, such as aspirin or metformin, against pancreatic cancer. As many patients use a combination of these drugs, one might speculate that the association between simvastatin and overall ...
Archibugi, L, Capurso, G, DELLE FAVE, Gianfranco   +2 more
core   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China

Brazilian Journal of Infectious Diseases, 2017
This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections.
Qifeng Gui, Yunmei Yang, Jiajia Zhang
doaj   +1 more source

Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. [PDF]

, 2017
A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily,
Bloedon, LeAnne T., Duffy, Danielle, Dunbar, Richard L., Fogelman, Alan M., Movva, Rajesh, Navab, Mohamad, Norris, Robert B., Rader, Daniel J.   +7 more
core   +2 more sources