Results 61 to 70 of about 356,980 (295)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Using an incomplete block design to allocate lines to environments improves sparse genome‐based prediction in plant breeding

The Plant Genome, 2022
Genomic selection (GS) is a predictive methodology that trains statistical machine‐learning models with a reference population that is used to perform genome‐enabled predictions of new lines.
Osval Antonio Montesinos‐Lopez, Abelardo Montesinos‐Lopez, Ricardo Acosta, Rajeev K. Varshney, Alison Bentley, Jose Crossa   +5 more
doaj   +1 more source

Steiner t-designs for large t

, 2008
One of the most central and long-standing open questions in combinatorial design theory concerns the existence of Steiner t-designs for large values of t. Although in his classical 1987 paper, L.
A. Betten, A. Delandtsheer, D. Gorenstein, D. Livingstone, D. Pei, D.G. Higman, D.K. Ray-Chaudhuri, D.R. Hughes, D.R. Stinson, D.R. Stinson, F. Buekenhout, F. Buekenhout, G.-C. Rota, H. Lüneburg, H. Wielandt, J. Saxl, J. Tits, J.D. Dixon, J.H. Conway, L. Teirlinck, M. Hall Jr., M. Huber, M. Huber, M. Huber, M. Huber, M.W. Liebeck, M.W. Liebeck, N.D. Tuan, P. Dembowski, P. Kaski, P.J. Cameron, P.J. Cameron, P.J. Cameron, P.J. Cameron, P.J. Cameron, R.A. Fisher, R.E. Block, T.. Beth, W.C. Huffman, W.M. Kantor, W.M. Kantor   +40 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Towards Analyzable Design Paradigms for Chaos-Based Cryptographic Primitives

Journal of Cybersecurity and Privacy
Although many chaos-based cryptosystems have been proposed over the past decade, they have yet to gain traction in real-world applications. A key reason for this is that most designs rely on security through obscurity, with unnecessarily complex ...
Abubakar Abba, Je Sen Teh, Mohd Najwadi Yusoff, Adnan Anwar   +3 more
doaj   +1 more source

Statistical aspects of experimental designs implemented in designs [PDF]

, 2003
The report describes the statistical aspects of experimental designs used in an ...
Kristensen, K.
core  

Statistical Precoder Design for Space-Time-Frequency Block Codes in Multiuser MISO-MC-CDMA Systems [PDF]

IEEE Systems Journal, 2016
10 pages, 4 figures, 1 ...
Chen, Xiaoming, Wang, Xiumin
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Blocking and re-arrangement of pots in greenhouse experiments: which approach is more effective?

Plant Methods, 2019
Background Observations measured in field and greenhouse experiments always contain errors. These errors can arise from measurement error, local or positional conditions of the experimental units, or from the randomization of experimental units.
Jens Hartung, Juliane Wagener, Reiner Ruser, Hans-Peter Piepho   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source