Results 81 to 90 of about 3,498,021 (328)

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

On the use of receiver operating characteristic curve analysis to determine the most appropriate p value significance threshold

Journal of Translational Medicine
Background p value is the most common statistic reported in scientific research articles. Choosing the conventional threshold of 0.05 commonly used for the p value in research articles, is unfounded.
Farrokh Habibzadeh
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Data and statistical interpretation of the corrosion inhibition of n,n dimethylaminoethanol, aminobenzene and 2-amino-5-ethyl-1,3,4-thiadiazole compound [PDF]

, 2022
Roland Tolulope Loto, Roland Tolulope Loto   +1 more
openalex   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Implant Stability Changes During Early Phase of Healing and Suggested the Fast Time of Loading: A Clinical Trial Study with ITI SLA Implants

Frontiers in Dentistry, 2009
Objective: To assess the stability changes as a reflection of early healing around roughened- surface implants in human by resonance frequency analysis (RFA).
AR. Rokn, AAR. Rasouli Ghahroudi, AS. Miremadi, MJ. Kharazi fard, A. Mesgarzadeh   +4 more
doaj  

Data-adaptive discriminative feature localization with statistically guaranteed interpretation [PDF]

, 2023
Ben Dai, Xiaotong Shen, Lin Y. Chen, Chunlin Li, Wei Pan   +4 more
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Verifying Accuracy of Data Registration in Households\' Files Living in Rural Areas of Hamadan County in 2011

پزشکی بالینی ابن سینا, 2013
Introduction & Objective: Initial information is necessary for decision and policy making. A weak information system leads to poor decision-making but the accuracy of data registration and collection can be a valid supporter for assessing health system ...
Alireza Soltanian, Naser Fayyazi, Farah Khodakarami, Mahdi Maleki   +3 more
doaj  

A Statistical Framework to Predict Functional Non-Coding Regions in the Human Genome Through Integrated Analysis of Annotation Data

Scientific Reports, 2015
Identifying functional regions in the human genome is a major goal in human genetics. Great efforts have been made to functionally annotate the human genome either through computational predictions, such as genomic conservation, or high-throughput ...
Q. Lu, Yiming Hu, Jiehuan Sun, Yuwei Cheng, K. Cheung, Hongyu Zhao   +5 more
semanticscholar   +1 more source