Statistical design of experiments

Results 61 to 70 of about 167,868,153 (286)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source

Densification of Expanded Polystyrene Waste Using Organic Solvents, a Sustainable Recycling Strategy

Eng
Expanded polystyrene (EPS) is a material with a wide range of applications in different sectors of everyday life and in industry. EPS is a major environmental challenge, as the properties that give it versatility of use make it a difficult waste to ...
Romeo Garcia-Cruz +5 more
doaj +1 more source

Optimization of Arabian-Shield-Based Natural Pozzolan and Silica Fume for High-Performance Concrete Using Statistical Design of Experiments

Advances in Civil Engineering, 2021
In this study, the optimum dosages of silica fume (SF) and natural pozzolan (NP) were experimentally and statistically assessed for the best strength and durability properties of high-performance concrete (HPC). SF and NP were used as partial replacement
Yassir M. Abbas, M. Iqbal Khan
doaj +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source

Statistical Design of Experiments Enables Rapid Exploration of Perfluorobutane Sulfonate Degradation

ECS Advances
The phase-out of long-chain PFAS has led to the proliferation of highly recalcitrant short-chain analogs, and mineralization technologies for these short-chain PFAS are needed to mitigate their deleterious effects on environmental and human health.
Rachel N. Gaines +5 more
doaj +1 more source

An energetic approach to the statistical analysis and optimization of friction welding processes applied to an aluminum-steel-joint

Journal of Advanced Joining Processes
The present publication deals with an energy-oriented approach to the statistical analysis of rotational friction welding processes. To illustrate the methodological approach, it is applied to investigate the effects of energy flow on material flow ...
M. Winkler +5 more
doaj +1 more source

Statistical Investigation of Mechanical Characteristics of Polymer Concrete Using Mixture Design of Experiments [PDF]

Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2007
The aim of this paper is to present an approach for developing material models, using a statistical investigation, for analysing the mechanical characteristics of polymer concrete.
Daniel Lepădatu, Marinela Bărbuţă
doaj

Statistical protein quantification and significance analysis in label-free LC-MS experiments with complex designs

BMC Bioinformatics, 2012
Background Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is widely used for quantitative proteomic investigations. The typical output of such studies is a list of identified and quantified peptides.
Clough Timothy +4 more
doaj +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source

design of experiments
statistical analysis
design of experiments doe

response surface methodology
factorial design