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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source

Measurement of the W boson mass

Journal of High Energy Physics, 2022
The W boson mass is measured using proton-proton collision data at s $$ \sqrt{s} $$ = 13 TeV corresponding to an integrated luminosity of 1.7 fb −1 recorded during 2016 by the LHCb experiment.
The LHCb collaboration +1011 more
doaj +1 more source

General Distribution Theory of the Concomitants of Order Statistics

The Annals of Statistics, 1977
Let $(X_i, Y_i) (i = 1, 2, \cdots, n)$ be $n$ independent $\mathrm{rv}$'s from some bivariate distribution. If $X_{r:n}$ denotes the $r$th ordered $X$-variate, then the $Y$-variate $Y_{\lbrack r:n\rbrack}$ paired with $X_{r:n}$ is termed the concomitant of the $r$th order statistics.
openaire +3 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source

New Lifetime Alpha Power Exponential Weibull Distribution: Structure and Properties

Ibn Al-Haitham Journal for Pure and Applied Sciences
In statistics theory, adding a new parameter is considered one of the important things that help in producing statistical distributions more flexible and appropriate in data analysis.
Hiba Mahdi Saleh +2 more
doaj +1 more source

Maximum Configuration Principle for Driven Systems with Arbitrary Driving

Entropy, 2018
Depending on context, the term entropy is used for a thermodynamic quantity, a measure of available choice, a quantity to measure information, or, in the context of statistical inference, a maximum configuration predictor.
Rudolf Hanel, Stefan Thurner
doaj +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source

Statistical theory of self-similarly distributed fields [PDF]

Physics Letters A, 2009
A field theory is built for self-similar statistical systems with both generating functional being the Mellin transform of the Tsallis exponential and generator of the scale transformation that is reduced to the Jackson derivate. With such a choice, the role of a fluctuating order parameter is shown to play deformed logarithm of the amplitude of a ...
Oliemskoi, Oleksandr Ivanovych, Shuda, Iryna Oleksandrivna +1 more
openaire +5 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source

statistical mechanics