Results 91 to 100 of about 3,450,267 (350)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Statistical inference and statistical learning in economic research – selected challenges

Ekonomista
This paper presents the main trends and the most important challenges related to the use of classical and modern statistical methods in economic research.
Krzysztof Jajuga, Józef Pociecha, Mirosław Szreder   +2 more
doaj   +1 more source

Pengaruh Komitmen Organisasi Dan Gaya Kepemimpinan Terhadap Hubungan Antara Partisipasi Anggaran Dan Kinerja Manajerial [PDF]

, 2013
This study aims to prove allegations that a manager's leadership style and organizational commitment as a moderating variable may moderate the relationship between budgetary participation on managerial performance in manufacturing companies in the city ...
., Yunita
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

A Note on Statistical Hypothesis Testing: Probabilifying Modus Tollens Invalidates Its Force? Not True! [PDF]

Educ Psychol Meas, 2023
Widaman KF.
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Interpreting Results from Statistical Hypothesis Testing: Understanding the Appropriate P-value. [PDF]

Phys Ther Res, 2022
Tsushima E.
europepmc   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Smart strategy in statistics: choosing appropriate test tools for data and hypotheses in quantitative research

JPPI (Jurnal Penelitian Pendidikan Indonesia)
The selection of appropriate statistical test tools is a major challenge in quantitative research, and errors in their selection can affect the validity and reliability of research results.
Nana Darna, Iwan Setiawan, M. Aziz Basari, Kasman Kasman   +3 more
doaj   +1 more source

Searching for Significance in the Scholarship of Teaching and Learning and Finding None: Understanding Non-Significant Results

Teaching & Learning Inquiry: The ISSOTL Journal, 2016
Quantitative results from empirical studies are common in the field of Scholarship of Teaching and Learning (SoTL), but it is important to remain aware of what the results from our studies can, and cannot, tell us. Oftentimes studies conducted to examine
April McGrath
doaj   +1 more source