Results 71 to 80 of about 1,875,600 (283)

On testing the equality of high dimensional mean vectors with unequal covariance matrices [PDF]

open access: yes, 2015
In this article, we focus on the problem of testing the equality of several high dimensional mean vectors with unequal covariance matrices. This is one of the most important problem in multivariate statistical analysis and there have been various tests ...
Bai, Zhidong   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Evaluating divorce dynamics through ODE modeling and statistical hypothesis testing

open access: yesDiscover Applied Sciences
To understand divorce, a quantitative method is used which considers the social, economic, and psychological elements impacting marital changes. We introduce a model based on Ordinary Differential Equations (ODEs), combined with statistical hypothesis ...
Ausif Padder   +5 more
doaj   +1 more source

Manipulating the Alpha Level Cannot Cure Significance Testing

open access: yesFrontiers in Psychology, 2018
We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = 0.05 to p = 0.005, is deleterious for the finding of new discoveries and the progress of science.
David Trafimow   +67 more
doaj   +1 more source

On hypothesis testing for statistical model checking

open access: yesInternational Journal on Software Tools for Technology Transfer, 2014
Hypothesis testing is an important part of statistical model checking (SMC). It is typically used to verify statements of the form $p>p_0$ or $p<p_0$, where $p$ is an unknown probability intrinsic to the system model and $p_0$ is a given threshold value. Many techniques for this have been introduced in the SMC literature.
Daniël Reijsbergen   +3 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Power-law distributions in binned empirical data

open access: yes, 2014
Many man-made and natural phenomena, including the intensity of earthquakes, population of cities and size of international wars, are believed to follow power-law distributions.
Clauset, Aaron, Virkar, Yogesh
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Hypothesis testing, type I and type II errors

open access: yesIndustrial Psychiatry Journal, 2009
Hypothesis testing is an important activity of empirical research and evidence-based medicine. A well worked up hypothesis is half the answer to the research question.
Amitav Banerjee   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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