Results 61 to 70 of about 1,875,600 (283)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Significance testing without truth [PDF]
, 2013 A popular approach to significance testing proposes to decide whether the given hypothesized statistical model is likely to be true (or false). Statistical decision theory provides a basis for this approach by requiring every significance test to make a ...
Perkins, William +2 more
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Statistical significance and statistical power in hypothesis testing [PDF]
Journal of Orthopaedic Research, 1990 AbstractExperimental design requires estimation of the sample size required to produce a meaningful conclusion. Often, experimental results are performed with sample sizes which are inappropriate to adequately support the conclusions made. In this paper, two factors which are involved in sample size estimation are detailed—namely type I (α) and type II
openaire +2 more sources
Understanding Statistical Hypothesis Testing: The Logic of Statistical Inference [PDF]
Machine Learning and Knowledge Extraction, 2019 Statistical hypothesis testing is among the most misunderstood quantitative analysis methods from data science. Despite its seeming simplicity, it has complex interdependencies between its procedural components. In this paper, we discuss the underlying logic behind statistical hypothesis testing, the formal meaning of its components and their ...
Frank Emmert-Streib, Matthias Dehmer
openaire +3 more sources
, 2012 The RooStats toolkit, which is distributed with the ROOT software package, provides a large collection of software tools that implement statistical methods commonly used by the High Energy Physics community.
Schott, Grégory
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Pitfalls of statistical hypothesis testing: multiple testing [PDF]
BMJ, 2014 The effectiveness of a home based intervention on children’s body mass index (BMI) at age 2 years was investigated. A randomised controlled superiority trial was used. The intervention consisted of eight home visits from specially trained community nurses in the first 24 months after birth.
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Statistical Hypothesis Testing: A Comprehensive Review of Theory, Methods, and Applications
MathematicsStatistical hypothesis testing is a foundational concept in inferential statistics, providing formal mechanisms for evaluating evidence and making decisions.
Vesna Rajić
doaj +1 more source