Driving Regional Economic Models with a Statistical Model: Hypothesis Testing for Economic Impact Analysis [PDF]
, 2002 Stephan Weiler +3 more
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
A New Soft Approach for Statistical Hypothesis Testing Problems With Data Fusion Using Neyman Pearson Criterion [PDF]
, 2003 A. Mamdouh
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Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Revisiting Differentially Private Hypothesis Tests for Categorical Data [PDF]
arXiv, 2015 In this paper, we consider methods for performing hypothesis tests on data protected by a statistical disclosure control technology known as differential privacy. Previous approaches to differentially private hypothesis testing either perturbed the test statistic with random noise having large variance (and resulted in a significant loss of power) or ...
arxiv
Bias toward the Null Hypothesis in Model-Free Linkage Analysis Is Highly Dependent on the Test Statistic Used [PDF]
, 2004 Heather J. Cordell
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Sample size and significance – somewhere between statistical power and judgment prostration
Archives of Medical Science, 2007 When performing scientific research we are so “embraced” to use the tool of inductive logic in our reasoning that we often express more generalized opinions on the population of interest based on relatively small sample(s) of a general population.
Cezary Watała
doaj
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Well‐being on supportive techniques in amyotrophic lateral sclerosis: from neurologists' perspective
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1874-1883, December 2022., 2022 Abstract Objective To investigate intercultural neurologists' perception of well‐being in patients with amyotrophic lateral sclerosis (ALS) using gastrostomy (PEG), non‐invasive, and/or invasive ventilation (NIV/IV) and to analyse the determinants and impact on the management of the above medical interventions (MIs).
Krzysztof Barć +7 more
wiley +1 more source