Results 51 to 60 of about 419,428 (264)

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

open access: yesMolecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina   +17 more
wiley   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

Errors in Statistical Inference Under Model Misspecification: Evidence, Hypothesis Testing, and AIC

open access: yesFrontiers in Ecology and Evolution, 2019
The methods for making statistical inferences in scientific analysis have diversified even within the frequentist branch of statistics, but comparison has been elusive.
Brian Dennis   +4 more
doaj   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Differentially Private Kolmogorov-Smirnov-Type Tests [PDF]

open access: yesarXiv, 2022
Hypothesis testing is a central problem in statistical analysis, and there is currently a lack of differentially private tests which are both statistically valid and powerful. In this paper, we develop several new differentially private (DP) nonparametric hypothesis tests.
arxiv  

Wind Turbine Fault Detection through Principal Component Analysis and Statistical Hypothesis Testing

open access: yesEnergies, 2015
This paper addresses the problem of online fault detection of an advanced wind turbine benchmark under actuators (pitch and torque) and sensors (pitch angle measurement) faults of different type: fixed value, gain factor, offset and changed dynamics. The
Francesc Pozo, Yolanda Vidal
doaj   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Hypothesis Testing with Finite Statistics

open access: yesThe Annals of Mathematical Statistics, 1969
Let $X_1, X_2, \cdots$ be a sequence of independent identically distributed random variables drawn according to a probability measure $\mathscr{P}$. The two-hypothesis testing problem $H_0: \mathscr{P} = \mathscr{P}_0 \operatorname{vs.} H_1: \mathscr{P} = \mathscr{P}_1$ is investigated under the constraint that the data must be summarized after each ...
openaire   +3 more sources

Deviation from Benfords law and identification of author peculiarities in texts [PDF]

open access: yesКомпьютерные исследования и моделирование, 2015
The distribution of the first significant digit in numerals of connected texts is considered. Benford's law is found to hold approximately for them.
Andrei Viacheslavovich Zenkov
doaj   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

open access: yesMolecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy