Results 51 to 60 of about 618,680 (239)
Manipulating the Alpha Level Cannot Cure Significance Testing
Frontiers in Psychology, 2018 We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = 0.05 to p = 0.005, is deleterious for the finding of new discoveries and the progress of science.
David Trafimow +67 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Statistical significance and its meaning [PDF]
Psihološka Obzorja, 2005 The most frequently method of data analysis in psychology is null hypothesis significance testing (NHST); this work identifies the misunderstandings and consequent biases due to the unwitting use of this hybrid approach, derived by the fusion of the p ...
Christina Bachmann +2 more
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
F1000ResearchFailure to reject a null-hypothesis may lead to erroneous conclusions regarding the absence of an association or inadequate statistical power. Because an estimate (and its variance) can never be exactly zero, traditional statistical tests cannot ...
Amand Schmidt
doaj +1 more source
Hypothesis testing, type I and type II errors
Industrial Psychiatry Journal, 2009 Hypothesis testing is an important activity of empirical research and evidence-based medicine. A well worked up hypothesis is half the answer to the research question.
Amitav Banerjee +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
F1000ResearchFailure to reject a null-hypothesis may lead to erroneous conclusions regarding the absence of an association or inadequate statistical power. Because an estimate (and its variance) can never be exactly zero, traditional statistical tests cannot ...
Amand Schmidt
doaj +1 more source
Hypothesis Testing with Finite Statistics
The Annals of Mathematical Statistics, 1969 Let $X_1, X_2, \cdots$ be a sequence of independent identically distributed random variables drawn according to a probability measure $\mathscr{P}$. The two-hypothesis testing problem $H_0: \mathscr{P} = \mathscr{P}_0 \operatorname{vs.} H_1: \mathscr{P} = \mathscr{P}_1$ is investigated under the constraint that the data must be summarized after each ...
openaire +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source