Results 61 to 70 of about 3,450,267 (350)
New Physical Implications From Revisiting Foreshock Activity in Southern California
Geophysical Research Letters, 2023 Foreshock analysis promises new insights into the earthquake nucleation process and could potentially improve earthquake forecasting. Well‐performing clustering models like the Epidemic‐Type Aftershock Sequence (ETAS) model assume that foreshocks and ...
Ester Manganiello +2 more
doaj +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Deviation from Benfords law and identification of author peculiarities in texts [PDF]
Компьютерные исследования и моделирование, 2015 The distribution of the first significant digit in numerals of connected texts is considered. Benford's law is found to hold approximately for them.
Andrei Viacheslavovich Zenkov
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
HyPhy 2.5 - a customizable platform for evolutionary hypothesis testing using phylogenies.
Molecular biology and evolution, 2019 hyphy (HYpothesis testing using PHYlogenies) is a scriptable, open-source package for fitting a broad range of evolutionary models to multiple sequence alignments, and for conducting subsequent parameter estimation and hypothesis testing, primarily in ...
Sergei L. Kosakovsky Pond +13 more
semanticscholar +1 more source
Effectiveness of Measures of Performance During Speculative Bubbles
, 2007 Statistical analysis of financial data most focused on testing the validity of Brownian motion (Bm). Analysis performed on several time series have shown deviation from the Bm hypothesis, that is at the base of the evaluation of many financial ...
Petroni, Filippo, Rotundo, Giulia
core +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
, 2015 We investigate the weak measurement experiment demonstrated by Ritchie et al. [N. W. M. Ritchie, J. G. Story, and R. G. Hulet, Phys. Rev. Lett. 66, 1107 (1991)] from the viewpoint of the statistical hypothesis testing for the weak-value amplification ...
Susa, Yuki
core +1 more source