Results 101 to 110 of about 53,985 (263)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Hypersurfaces in statistical manifolds

Differential Geometry and its Applications, 2009
A statistical structure on a manifold \(M\) consists of a Riemannian metric \(g\) and a torsion-free affine connection \(\nabla\) that satisfies \( (\nabla_Xg)(Y,Z) = (\nabla_Yg)(X,Z)\) for all vector fields \(X\), \(Y\), and \(Z\) on \(M\). The statistical manifold \((M, \nabla, g)\) has constant curvature \(k\) if \[ R^\nabla(X,Y)Z = k(g(Y,Z)X-g(X,Z ...
openaire   +3 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

α-Connections and a Symmetric Cubic Form on a Riemannian Manifold

Entropy, 2017
In this paper, we study the construction of α -conformally equivalent statistical manifolds for a given symmetric cubic form on a Riemannian manifold.
Keiko Uohashi
doaj   +1 more source

Geometry of statistical manifolds

Differential Geometry and its Applications, 1992
A statistical manifold \((M,g,\nabla)\) is a Riemannian manifold \((M,g)\) equipped with torsion-free affine connections \(\nabla,\nabla^*\) which are dual with respect to \(g\). A point \(p\in M\) is said to be \(\nabla\)- isotropic if the sectional curvatures have the same value \(k(p)\), and \((M,g,\nabla)\) is said to be \(\nabla\)-isotropic when \(
openaire   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Para-Holomorphic Statistical Structure with Cheeger Gromoll Metric

Mathematics
We consider the family of λ connections ∇(λ) on a statistical manifold M equipped with a pair of conjugate connections ∇=∇(1) and ∇*=∇(−1), where the λ connection is defined as ∇(λ)=1+λ2∇+1−λ2∇*.
Esmaeil Peyghan, Leila Nourmohammadifar, Ion Mihai   +2 more
doaj   +1 more source