Results 111 to 120 of about 132,756 (302)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Statistical Mechanics-Based Schrödinger Treatment of Gravity
Entropy, 2019 The entropic gravity conception proposes that what has been traditionally interpreted as unobserved dark matter might be merely the product of quantum effects.
Angelo Plastino, M. C. Rocca
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Inferential vs. Dynamical Conceptions of Physics [PDF]
, 2013 I contrast two possible attitudes towards a given branch of physics: as inferential (i.e., as concerned with an agent's ability to make predictions given finite information), and as dynamical (i.e., as concerned with the dynamical equations governing ...
Wallace, David, David Wallace
core
Thermodynamics and Statistical Mechanics of Small Systems
Entropy, 2018 A challenging frontier in modern statistical physics is concerned with systems with a small number of degrees of freedom, far from the thermodynamic limit.[...]
Andrea Puglisi +2 more
doaj +1 more source
Covariant statistical mechanics
Il Nuovo Cimento B Series 10, 1968 1. The relativistic t ransformation properties of thermodynamical quantities have been discussed even before the advent of the special theory of relativity. In 1904 HASENOEHRL (1) derived a formula for the spectral intensi ty of the radiation emit ted from a moving black body. By 1919 the problem seemed to be solved and clearly understood: a chapter in
openaire +2 more sources
Statistical mechanics of interfering links [PDF]
Physical Review E, 2005 4 pages, 3 ...
openaire +3 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source