Results 121 to 130 of about 3,502,217 (294)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Statistical Mechanics-Based Schrödinger Treatment of Gravity

Entropy, 2019
The entropic gravity conception proposes that what has been traditionally interpreted as unobserved dark matter might be merely the product of quantum effects.
Angelo Plastino, M. C. Rocca
doaj   +1 more source

The scientific way of thinking in statistics, statistical physics and quantum mechanics [PDF]

This paper focuses on the way of thinking in both classical and modern Physics and Statistics, Statistical Mechanics or Statistical Physics and Quantum Mechanics.
Săvoiu, Gheorghe
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Thermodynamics and Statistical Mechanics of Small Systems

Entropy, 2018
A challenging frontier in modern statistical physics is concerned with systems with a small number of degrees of freedom, far from the thermodynamic limit.[...]
Andrea Puglisi, Alessandro Sarracino, Angelo Vulpiani   +2 more
doaj   +1 more source

BEC IN NONEXTENSIVE STATISTICAL MECHANICS [PDF]

International Journal of Modern Physics B, 2000
We discuss the Bose–Einstein condensation (BEC) for an ideal gas of bosons in the framework of Tsallis's nonextensive statistical mechanics. We study the corrections to the st and ard BEC formulas due to a weak nonextensivity of the system. In particular, we consider three cases in the D-dimensional space: the homogeneous gas, the gas in a harmonic ...
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Ergodic hypothesis in classical statistical mechanics

Revista Brasileira de Ensino de Física
An updated discussion on physical and mathematical aspects of the ergodic hypothesis in classical equilibrium statistical mechanics is presented. Then a practical attitude for the justification of the microcanonical ensemble is indicated.
César R. de Oliveira, Thiago Werlang
doaj   +1 more source

Matrix inequalities in statistical mechanics

Linear Algebra and its Applications, 2004
The main results of this paper are a straightforward proof of the thermodynamic inequality and a derivation of the equivalence of this inequality to the Peierls-Bogolyubov inequality.
Bebiano, N., Providência Jr., J., Lemos, Rute   +2 more
openaire   +4 more sources