Results 41 to 50 of about 5,428,123 (293)

Unraveling the metastasis‐preventing effect of miR‐200c in vitro and in vivo

Molecular Oncology, EarlyView.
Advanced tumors and ineffective cancer treatments can lead to metastases in distant organs. The sole expression of microRNA 200c (miR‐200c) in breast cancer cells is shown to significantly reduce metastasis formation in xenograft mouse models. Various in vitro analyses revealed impeded migratory behavior, upon miR‐200c expression, as one prerequisite ...
Bianca Köhler, Emily Brieger, Tom Brandstätter, Elisa Hörterer, Ulrich Wilk, Jana Pöhmerer, Anna Jötten, Philipp Paulitschke, Chase P. Broedersz, Stefan Zahler, Joachim O. Rädler, Ernst Wagner, Andreas Roidl   +12 more
wiley   +1 more source

General relativistic statistical mechanics

, 2012
Understanding thermodynamics and statistical mechanics in the full general relativistic context is an open problem. I give tentative definitions of equilibrium state, mean values, mean geometry, entropy and temperature, which reduce to the conventional ...
Rovelli, Carlo
core   +3 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Generalized statistical mechanics for superstatistical systems [PDF]

, 2010
Mesoscopic systems in a slowly fluctuating environment are often well described by superstatistical models. We develop a generalized statistical mechanics formalism for superstatistical systems, by mapping the superstatistical complex system onto a system of ordinary statistical mechanics with modified energy levels.
arxiv   +1 more source

Robert W. Zwanzig: Formulated nonequilibrium statistical mechanics [PDF]

Proc. Natl. Acad. Sci. USA 111, 115672 (2014), 2014
This article is a brief Retrospective on the life and work of Robert W. Zwanzig, who formulated nonequilibrium statistical mechanics and who passed away in May of this year.
arxiv   +1 more source

Statistical mechanics of voting

, 1998
Decision procedures aggregating the preferences of multiple agents can produce cycles and hence outcomes which have been described heuristically as `chaotic'.
B. Hasslacher, B. Ward, C. E. Shannon, C. E. Shannon, D. Black, D. C. McGarvey, D. G. Saari, D. Richards, D. Ruelle, David A. Meyer, E. C. Browne, E. P. Wigner, E. V. Huntington, F. J. Dyson, G. Chichilnisky, G. Chichilnisky, G. Th. Guilbaud, J.-C. de Borda, K. J. Arrow, L. A. Goodman, L. Cohen, M. J. A. N. de Caritat, Marquis de Condorcet, M. L. Mehta, M. Misiurewicz, N. Schofield, P. C. Fishburn, R. D. McKelvey, R. D. McKelvey, R. Farquharson, R. L. Adler, R. M. May, T. Li, Thad A. Brown, W. H. Gottshalk, W. Parry, W. V. Gehrlein, Y. M. Baryshnikov   +36 more
core   +3 more sources

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Covariant Equilibrium Statistical Mechanics

, 2006
A manifest covariant equilibrium statistical mechanics is constructed starting with a 8N dimensional extended phase space which is reduced to the 6N physical degrees of freedom using the Poincare-invariant constrained Hamiltonian dynamics describing the ...
Barut A. O., de Groot S. R., E. Lehmann, Gitman D. M., Gradsteyn I. S., Hanson A., Havas P., Henneaux M., Horwitz L. P., Huang K., Münster A., Stückelberg E. C. G., Sundermeyer K.   +12 more
core   +1 more source

Statistical Origin of Quantum Mechanics [PDF]

, 2001
The one particle quantum mechanics is considered in the frame of a N-body classical kinetics in the phase space. Within this framework, the scenario of a subquantum structure for the quantum particle, emerges naturally, providing an ontological support ...
Aldrovandi, Bohm, Bohm, Bohm, Dankel, Davies, de Broglie, Fenyes, G. Kaniadakis, Garbaczewski, Garbaczewski, Ghosh, Gilson, Glassey, Hajra, Holland, Janossy, Janossy, Kan, Kershaw, Lafferty, Liboff, Madelung, Namsrai, Namsrai, Nelson, Nicholson, Reginatto, Sonego, Takabayasi, Takabayasi, Takabayasi, Wallstrom, Wallstrom, Wallstrom, Wilhelm, Wong   +36 more
core   +2 more sources

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

Molecular Oncology, EarlyView.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray   +12 more
wiley   +1 more source