Results 61 to 70 of about 702,199 (275)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Gears in chemical reaction networks for optimizing energy transduction efficiency
Nature CommunicationsSimilarly to gear systems in vehicles, most chemical reaction networks (CRNs) involved in energy transduction have at their disposal multiple transduction pathways, each characterized by distinct efficiencies. We conceptualize these pathways as ‘chemical
Massimo Bilancioni +1 more
doaj +1 more source
Stochastic thermodynamics of rapidly driven systems
New Journal of Physics, 2015 We present the stochastic thermodynamics analysis of an open quantum system weakly coupled to multiple reservoirs and driven by a rapidly oscillating external field.
Gregory Bulnes Cuetara +2 more
doaj +1 more source
Dynamical Temperature from the Phase Space Trajectory
Hungarian Journal of Industry and Chemistry, 2017 In classical statistical mechanics the trajectory in phase space represents the propagation of a classical Hamiltonian system. While trajectories play a key role in chaotic system theory, exploitation of a single trajectory has yet to be considered. This
Baranyai András
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Double quantum dot coupled to a quantum point contact: a stochastic thermodynamics approach
New Journal of Physics, 2015 We study the nonequilibrium properties of an electronic circuit composed of a double quantum dot (DQD) channel capacitively coupled to a quantum point contact (QPC) within the framework of stochastic thermodynamics.
Gregory Bulnes Cuetara +1 more
doaj +1 more source
Statistical mechanics of anharmonic lattices
, 2003 This paper is a review on the statistical mechanics of anharmonic oscillators coupled to heat reservoirs. We discuss stationary states (existence and ergodic properties) and entropy production (positivity, Green-Kubo formulas and the Gallavotti-Cohen ...
Dedicated Lawrence +2 more
core +2 more sources
Statistical Mechanics of Phase-Space Curves [PDF]
, 2013 We study the classical statistical mechanics of a phase-space curve. This unveils a mechanism that, via the associated entropic force, provides us with a simple realization of effects such as confinement, hard core, and asymptotic freedom.
Ferri, G. L., Plastino, A., Rocca, M.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Thermodynamically consistent coarse graining of biocatalysts beyond Michaelis–Menten
New Journal of Physics, 2018 Starting from the detailed catalytic mechanism of a biocatalyst we provide a coarse-graining procedure which, by construction, is thermodynamically consistent.
Artur Wachtel +2 more
doaj +1 more source