Results 21 to 30 of about 5,544 (263)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

STATISTICAL MECHANICS MODELING OF MESOSCALE DEFORMATION IN METALS [PDF]

, 2013
The research under this project focused on a theoretical and computational modeling of dislocation dynamics of mesoscale deformation of metal single crystals.
El-Azab, Anter
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

From the Variational Principle to the Legendre Transform: A Revisit of the Wulff Construction and Its Computational Realization

Crystals
The equilibrium shape of a crystal is a fundamental problem in materials science and condensed matter physics. The Wulff construction, a cornerstone of crystal morphology prediction, is traditionally presented and utilized as a powerful geometric ...
Hao Wu, Zhong-Can Ou-Yang
doaj   +1 more source

Statistical mechanical model of gas adsorption in porous crystals with dynamic moieties [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Some nanoporous, crystalline materials possess dynamic/flexible constituents, for example, a ligand that can rotate. Much like the induced-fit model of enzyme–substrate binding in biology, these dynamic moieties often change conformation when gas molecules adsorb.
Simon, Cory M., Braun, Efrem, Carraro, Carlo, Smit, Berend   +3 more
openaire   +4 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Nematic Twist-Bend Phase with Nanoscale Modulation of Molecular Orientation [PDF]

, 2013
Peer ...
Panov, V P, Jákli, A., Panov, V. P., Kim, Y K, Imrie, C T, Mehl, G H, Imrie, C. T., Tamba, M. G., Tampa, M G, Lavrentovich, O D, Lavrentovich. O. D., Jakli, A, Xiang, J., Xiang, J, Mehl, G. H., Vij, J K, Gao, M., Vij, J. K., Kim, Y. -K., Lavrentovich, O. D., KIM, YOUNGKI, Borshch, V.   +21 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Computer simulation of liquid crystals [PDF]

, 1999
Molecular dynamics simulation performed on modern computer workstations provides a powerful tool for the investigation of the static and dynamic characteristics of liquid crystal phases.
M(^c)Bride, Carl
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source