Results 41 to 50 of about 5,577 (263)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
PLoS ONE, 2014 X-ray crystallography is the predominant method for obtaining atomic-scale information about biological macromolecules. Despite the success of the technique, obtaining well diffracting crystals still critically limits going from protein to structure. In practice, the crystallization process proceeds through knowledge-informed empiricism. Better physico-
Fusco, Diana +6 more
openaire +7 more sources
Identities for Correlation Functions in Classical Statistical Mechanics and the Problem of Crystal States [PDF]
Journal of Statistical Physics, 2020 Let $z$ be the activity of point particles described by classical equilibrium statistical mechanics in ${\bf R}^ν$. The correlation functions $ρ^z(x_1,\dots,x_k)$ denote the probability densities of finding $k$ particles at $x_1,\dots,x_k$. Letting $ϕ^z(x_1,\dots,x_k)$ be the cluster functions corresponding to the $ρ^z(x_1,\dots,x_k)/z^k$ we prove ...
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Measurement of the Rare Transition b→sγ Using the Complete BABAR Data Set [PDF]
, 2011 We present the results of a measurement of the total rate and photon energy spectrum in b -> sγ transitions using the entire BABAR data set, 429 fb-1.
Doll, David Andrew
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
What Is a Macrostate? Subjective Observations and Objective Dynamics [PDF]
, 2003 We consider the question of whether thermodynamic macrostates are objective consequences of dynamics, or subjective reflections of our ignorance of a physical system.
Moore, Cristopher +3 more
core
Classical infrared spectra of ionic crystals and their relevance for statistical mechanics [PDF]
Physica A: Statistical Mechanics and its Applications, 2018 Sent for publication in Physica ...
Carati, Andrea +4 more
openaire +4 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Electronic Structure and Phonon Thermodynamics of Iron Alloys [PDF]
, 2013 Inelastic neutron scattering (INS) and nuclear-resonant inelastic x-ray scattering (NRIXS) were used to measure phonon spectra of FeV as a B2- ordered compound and as a bcc solid solution.
Muñoz, Jorge Alberto
core +1 more source