Results 31 to 40 of about 69,527 (244)

From the Variational Principle to the Legendre Transform: A Revisit of the Wulff Construction and Its Computational Realization

Crystals
The equilibrium shape of a crystal is a fundamental problem in materials science and condensed matter physics. The Wulff construction, a cornerstone of crystal morphology prediction, is traditionally presented and utilized as a powerful geometric ...
Hao Wu, Zhong-Can Ou-Yang
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Entangled photons, nonlocality and Bell inequalities in the undergraduate laboratory

, 2002
We use polarization-entangled photon pairs to demonstrate quantum nonlocality in an experiment suitable for advanced undergraduates. The photons are produced by spontaneous parametric downconversion using a violet diode laser and two nonlinear crystals ...
Bell J. S., Dietrich Dehlinger, M. W. Mitchell, Zel’dovich B. Ya.   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Thermal conduction in classical low-dimensional lattices

, 2003
Deriving macroscopic phenomenological laws of irreversible thermodynamics from simple microscopic models is one of the tasks of non-equilibrium statistical mechanics.
Lepri, Stefano, Livi, Roberto, Politi, Antonio   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

On the critical nature of plastic flow: one and two dimensional models

, 2012
Steady state plastic flows have been compared to developed turbulence because the two phenomena share the inherent complexity of particle trajectories, the scale free spatial patterns and the power law statistics of fluctuations.
Acharya, Ananthakrishna, Argon, Bak, Baret, Barnsley, Ben-Zion, Ben-Zion, Berdichevsky, Bharathi, Bharathi, Blanc, Born, Braides, Brinckmann, Bréchet, Cahn, Cahn, Carpio, Carpio, Carrillo, Chan, Charlotte, Chen, Chen, Chen, Choi, Ciamarra, Clauset, Colaiori, Colaiori, Conti, Cottrell, Cottrell, Csikor, Dahmen, Dahmen, Dahmen, Delaplace, Dhar, Dhar, Dickman, Dimiduk, Dimiduk, Falk, Fedelich, Fey, Fisher, Fisher, Fisher, Fressengeas, Groma, Hamon, Henkel, Hentschel, Hill, Hirth, Houston, Hwa, Hähner, Ispánovity, Jakobsen, Jarai, Jensen, Kachanov, Kardar, Kartha, Kertesz, Kobayashi, Koslowski, Koslowski, Koslowski, Kovalev, Kresse, Kubin, Kubin, Kuntz, L. Truskinovsky, Landau, Landau, Laurson, Laurson, Le Doussal, Le Doussal, Limkumnerd, Limkumnerd, Limkumnerd, Liu, Lookman, Lubliner, Maeda, Maeda, Malandro, Maloney, Maloney, Maslov, Mehta, Mielke, Miguel, Miguel, Miyazaki, Moretti, Motz, Mueller, Mughrabi, Nabarro, Nabarro, Nadgorny, Narayan, Needleman, Ng, O.U. Salman, Onuki, Ortiz, Pagano, Papanikolaou, Patinet, Pellegrini, Pertsinidis, Plans, Prandtl, Procaccia, Puglisi, Puglisi, Puglisi, Pérez-Reche, Pérez-Reche, Pérez-Reche, Pérez-Reche, Rasmussen, Redig, Ren, Rice, Richeton, Richeton, Richeton, Rogers, Roy, Salman, Seeger, Sethna, Sethna, Shishvan, Sornette, Suziki, Talamali, Tanguy, Truskinovsky, Truskinovsky, Truskinovsky, Turcotte, Vainchtein, Vives, Weiss, Weiss, Weiss, Weiss, Weiss, Yamamoto, Zaiser, Zaiser, Zaiser, Zaiser, Zaiser, Zaiser, Zapperi, Zhou   +166 more
core   +3 more sources

Limit of validity of Ostwald's rule of stages in a statistical mechanical model of crystallization [PDF]

The Journal of Chemical Physics, 2011
We have only rules of thumb with which to predict how a material will crystallize, chief among which is Ostwald's rule of stages. It states that the first phase to appear upon transformation of a parent phase is the one closest to it in free energy.
Hedges, Lester O., Whitelam, Stephen
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source