Results 91 to 100 of about 15,642,380 (303)

The invariances of power law size distributions [version 3; referees: 2 approved]

F1000Research, 2016
Size varies. Small things are typically more frequent than large things. The logarithm of frequency often declines linearly with the logarithm of size. That power law relation forms one of the common patterns of nature.
Steven A. Frank
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Invariant death [version 1; referees: 2 approved]

F1000Research, 2016
In nematodes, environmental or physiological perturbations alter death’s scaling of time. In human cancer, genetic perturbations alter death’s curvature of time.
Steven A. Frank
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

What’s Past Is Prologue: A Scoping Review of Recent Public Health and Global Health Informatics Literature

, 2015
Objective: To categorize and describe the public health informatics (PHI) and global health informatics (GHI) literature between 2012 and 2014. Methods: We conducted a semi-systematic review of articles published between January 2012 and September ...
Gharghabi, Fardad, Dixon, Brian E., Kharrazi, Hadi, Pina, Jamie   +3 more
core   +1 more source

The invariances of power law size distributions [version 2; referees: 2 approved]

F1000Research, 2016
Size varies. Small things are typically more frequent than large things. The logarithm of frequency often declines linearly with the logarithm of size. That power law relation forms one of the common patterns of nature.
Steven A. Frank
doaj   +1 more source

Developing Causal Machine Learning Models in Health Informatics to Assess Social Determinants Driving Regional Health Inequities and Intervention Outcomes

Magna Scientia Advanced Biology and Pharmacy
Persistent regional health inequities stem from complex, interrelated social determinants such as income, education, housing, access to care, and environmental exposure.
R. Abi, J. Joseph
semanticscholar   +1 more source

[Microdatasus: a package for downloading and preprocessing microdata from Brazilian Health Informatics Department (DATASUS)].

Cadernos de Saúde Pública, 2019
This study aimed to develop an algorithm for downloading and preprocessing microdata furnished by the Brazilian Health Informatics Department (DATASUS) for various health information systems, using the R statistical programming language.
Raphael de Freitas Saldanha, R. Bastos, Christovam Barcellos   +2 more
semanticscholar   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Health informatics: an overview

, 1995
Health Informatics: an overview' reviews the basic concepts of informatics and the application of the technologies and methodologies of the information ssciences in healthcare.
Hovenga, Evelyn JS, B Cesnik (9892016), Kidd, M, Cesnik, B, M Kidd (9890474), Evelyn Hovenga (9805514)   +5 more
core