Results 81 to 90 of about 15,642,380 (303)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

What Do They Mean by "Health Informatics"? Health Informations Posts Compared to Program Standards

, 2017
There is a lack of alignment between and within the competencies and skills required by health informatics (HI) related jobs and those present in academic curriculum frameworks.
Kulanthaivel, Anand, Jones, Josette F., Katta, Shilpa, Zhang, Enming   +3 more
core   +1 more source

Funding source and primary outcome changes in clinical trials registered on ClinicalTrials.gov are associated with the reporting of a statistically significant primary outcome: a cross-sectional study [v2; ref status: indexed, http://f1000r.es/5bj]

F1000Research, 2015
Background: We and others have shown a significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates.
Sreeram V Ramagopalan, Andrew P. Skingsley, Lahiru Handunnetthi, Daniel Magnus, Michelle Klingel, Julia Pakpoor, Ben Goldacre   +6 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Developing WHO guidelines: Time to formally include evidence from mathematical modelling studies [version 2; referees: 2 approved]

F1000Research, 2018
In recent years, the number of mathematical modelling studies has increased steeply. Many of the questions addressed in these studies are relevant to the development of World Health Organization (WHO) guidelines, but modelling studies are rarely formally
Matthias Egger, Leigh Johnson, Christian Althaus, Anna Schöni, Georgia Salanti, Nicola Low, Susan L. Norris   +6 more
doaj   +1 more source

Multidisciplinary Approaches to Diabetes Mellitus Management: The Roles of Pharmacy, Nursing, Dentistry, Radiology, and Health Informatics-An Updated Review

Saudi Journal of Medicine and Public Health
Background: Diabetes mellitus remains a global health crisis with rising prevalence and substantial morbidity, mortality, and healthcare costs. The complexity of diabetes care, particularly in patients with comorbidities, necessitates integrated, team ...
Jameel Mohammed Sumaili, Ali Hamad Mohamad Sumaili, Badr Mohammed Kulaibi, Afnan Nasser Alhadili, Feras Saleh Dhaifallah Alsahli, Khalid Abdulsamad Hafiz, Mohammed Ahmed Ageeli, Areej Ibrahim Hassan Faqiri, Ahmed Nuwaifea Q. Aljohani, Yahya Qasem Essa Mangari   +9 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Prediction of influenza vaccine effectiveness for the influenza season 2017/18 in the US [version 1; referees: 2 approved]

F1000Research, 2017
Vaccination against seasonal influenza viruses is the most effective way to prevent infection. A key factor in the effectiveness of the seasonal influenza vaccine is its immunological compatibility with the circulating viruses during the season. The high
Slobodan Paessler, Veljko Veljkovic
doaj   +1 more source

Standardization and Interoperability: Federated Learning's Impact on EHR Systems and Health Informatics.

Advances in health information science and practice
Background In electronic health records (EHRs), standardization and interoperability challenges stem from fragmented data across institutions. Federated learning, a distributed machine learning framework through which multiple institutions can ...
Herat Joshi, Shenson Joseph
semanticscholar   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source