Results 151 to 160 of about 10,259,619 (287)

Survival Modeling Using Deep Learning, Machine Learning, and Statistical Methods: A Comparative Analysis for Predicting Mortality After Hospital Admission. [PDF]

Health Data Sci
Wang Z, Lee JW, Chakraborty T, Ning Y, Liu M, Xie F, Ong MEH, Liu N.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

STATISTICAL METHODS [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1999
openaire   +1 more source

Statistical methods for clustered competing risk data when the event types are only available in a training dataset. [PDF]

Stat Methods Med Res
Wu Y, Yang C, Wang M.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Exploration of Likert scale in terms of continuous variable with parametric statistical methods. [PDF]

BMC Med Res Methodol
Huh I, Gim J.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Statistical methods to harmonize electronic health record data across healthcare systems: case study and lessons learned. [PDF]

Bioinformatics
Shi X, Zhai Y, Yu X, Li X, Hazlehurst BL, Nyongesa DB, Sapp DS, Williamson BD, Carrell DS, Healy L, Cushing-Haugen KL, Wong J, Wang SV, Floyd JS, Shattuck K, McGown S, Alam S, Hernández-Muñoz JJ, Li J, Ma Y, Stojanovic D, Raman SR, Davis SE, Cai T, Nelson JC, Heagerty PJ.   +25 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Assessment of PlanetScope Spectral Data for Estimation of Peanut Leaf Area Index Using Machine Learning and Statistical Methods. [PDF]

Sensors (Basel)
Ekwe M, Fernando H, James G, Adeluyi O, Verrelst J, Kross A.   +5 more
europepmc   +1 more source