Results 141 to 150 of about 19,266,422 (304)
Quantitative Methods in Economics, 2014 In the process of calculation of the insurance premium in civil liability motor insurance the knowledge of distribution of the number and value of paid claims is required.
Anna Szymańska
doaj
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Statistical Policy Working Paper 1. Report on statistics for allocation of funds
This report examines the formulas used in allocating Federal funds to States and local areas. To understand the behavior of these formulas, one must understand the various aspects of the data, such as definitions, methods of collection, and methods of ...
United States. Federal Committee on Statistical Methodology
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Comparative analysis of sigma-based, quantile-based and time series VaR estimators
Acta Universitatis Lodziensis. Folia Oeconomica, 2015 Since its inception at the end of the XX century, VaR risk measure has gained massive popularity. It is synthetic, easy in interpretation and offers comparability of risk levels reported by different institutions.
Marta Małecka
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Analyzing the Risk of Divorce among Divorced Women with Children Using Time-Dependent Cox Model [PDF]
Taḥqīqāt-i ̒Ulūm-i RaftārīAim and Background: Divorce is one of the harms that has various personal, psychological and social dimensions and severely affects children. Therefore, studies in this field are always of interest to researchers and policymakers in the field of family ...
Mahsa Saadati, Arezoo Bagheri
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source