Results 61 to 70 of about 20,940,267 (272)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Validating the backtests of risk measures [PDF]
, 2007 Paper presented at INFINITI Conference on International Finance 11-12 June 2007, Trinity College Dublin. Also presented at Financial Management Association Annual Meeting, Orlando, Florida , 18-20 October 2007Financial risk model evaluation or ...
Cotter, John, Zhong, Yan Ping
core +1 more source
On representing claims for coherent risk measures [PDF]
, 2007 We consider the problem of representing claims for coherent risk measures. For this purpose we introduce the concept of (weak and strong) time-consistency with respect to a portfolio of assets, generalizing the one defined in Delbaen [7]. In a similar
Berkaoui, Abdelkarem, Jacka, Saul D.
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Exponential Spectral Risk Measures [PDF]
Spectral risk measures are attractive risk measures as they allow the user to obtain risk measures that reflect their subjective risk-aversion. This paper examines spectral risk measures based on an exponential utility function, and finds that these risk
Cotter, John, Dowd, Kevin
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Optimization of Risk Measures [PDF]
We consider optimization problems involving coherent risk measures. We derive necessary and sufficient conditions of optimality for these problems, and we discuss the nature of the nonanticipativity constraints.
Andrzej Ruszczynski, Alexander Shapiro
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Releasing microdata: disclosure risk estimation, data masking and assessing utility
, 2009 Statistical Agencies need to make informed decisions when releasing sample microdata from social surveys with respect to the level of protection required in the data and the mode of access.
Shlomo, Natalie
core
Justifying Typicality Measures of Boltzmannian Statistical Mechanics and Dynamical Systems [PDF]
, 2013 A popular view in contemporary Boltzmannian statistical mechanics is to interpret the measures as typicality measures. In dynamical systems theory measures can similarly be interpreted as typicality measures.
Werndl, Charlotte
core +1 more source