Results 81 to 90 of about 20,940,267 (272)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Integrating Engineering Principles with Financial Asset Management: The Three-Sigma Approach in Financial Markets [PDF]

Iranian Journal of Finance
In an increasingly volatile and uncertain financial landscape, particularly within the cryptocurrency market, robust risk assessment methods are essential.
Seyed Jalal Tabatabaei
doaj   +1 more source

Coherent Risk Measures and Upper Previsions [PDF]

In this paper coherent risk measures and other currently used risk measures, notably Value-at-Risk (VaR), are studied from the perspective of the theory of coherent imprecise previsions.
Renato Pelessoni, Paolo Vicig
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Association of antipsychotic and antidepressant treatment with metabolic syndrome and 10 years' coronary heart disease risk

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2018
Background: Cardiovascular risk is becoming a growing concern in patients receiving psychotropic medications. An increased Framingham risk score (FRS) and 10-year coronary artery disease risk has been reported in patients suffering from mental diseases ...
Vivek Pratap Singh, Archana Javadekar, Suprakash Chaudhury, Daniel Saldanha   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Statistical inference and effect measures in abstracts of major HIV and AIDS journals, 1987–2022: A systematic review

Global Epidemiology
Objectives: With the emergence of HIV/AIDS journals, the development of the reporting of statistical inference and effect measures in published abstracts can be examined from the beginning in a new field. The aim of this study was to describe time trends
Andreas Stang, Henning Schäfer, Ahmad Idrissi-Yaghir, Christoph M. Friedrich, Matthew P. Fox   +4 more
doaj   +1 more source

Knowledge, behaviour change, and anticipated compliance regarding non-pharmaceutical interventions during pandemic of influenza A H1N1 in Delhi

Lung India, 2012
Context : Compliance for non-pharmaceutical interventions for containment of Influenza A H1N1 is determined by community understanding and accurate information by appropriate risk commu-nication strategy.
Rinku Sharma, Suminder Kaur, Alka Sodhi
doaj   +1 more source

Statistical semantics : Methods and applications

, 2019
This book discusses the application of various statistical methods to texts, rather than numbers, in various fields in behavioral science. It proposes an approach where quantitative methods are applied to data whereas previously such data were analyzed ...
Garcia, Danilo, Garcia, Danilo,, Sikström, Sverker   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source