Results 71 to 80 of about 22,432,265 (271)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Optimization of Risk Measures [PDF]
We consider optimization problems involving coherent risk measures. We derive necessary and sufficient conditions of optimality for these problems, and we discuss the nature of the nonanticipativity constraints.
Andrzej Ruszczynski, Alexander Shapiro
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Validating the backtests of risk measures [PDF]
, 2007 Paper presented at INFINITI Conference on International Finance 11-12 June 2007, Trinity College Dublin. Also presented at Financial Management Association Annual Meeting, Orlando, Florida , 18-20 October 2007Financial risk model evaluation or ...
Cotter, John, Zhong, Yan Ping
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Risk management of physical safety of the main oil pipeline linear part
Известия Томского политехнического университета: Инжиниринг георесурсов, 2019 Relevance of the work is caused bythe need to improve the efficiency of the physical protection system of linear part of the main oil pipeline (LCh MN) from committing acts of unlawful interference, in particular from 2003 to 2012, 4779 facts of ...
Ivan Kukalo, Sergey Grivtsov
doaj +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Statistical inference for some risk measures
, 2017 Recently, many risk measures have been developed for various types of risk based on multiple financial variables. However, statistical properties of these risk measures are not fully understood, and there are very few effective inference methods for them
Hou, Yanxi
core +1 more source
RISK RANKING OF OPEN-END INVESTMENT FUNDS IN THE REPUBLIC OF CROATIA
Economic Review, 2017 Risk is an unavoidable situation. Both individuals and business entities are exposed to various types of risk on a daily basis. Since business conducts in contemporary market conditions are characterized by an increasingly higher level of insecurity ...
Ivana Srdarević, Ivan Kristek
doaj +2 more sources