Results 91 to 100 of about 2,204,741 (325)

Association of antipsychotic and antidepressant treatment with metabolic syndrome and 10 years' coronary heart disease risk

open access: yesMedical Journal of Dr. D.Y. Patil Vidyapeeth, 2018
Background: Cardiovascular risk is becoming a growing concern in patients receiving psychotropic medications. An increased Framingham risk score (FRS) and 10-year coronary artery disease risk has been reported in patients suffering from mental diseases ...
Vivek Pratap Singh   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Data Systematization and Preliminary Analysis of Accidental Oil and Petroleum Product Spills in the Russian Arctic and Far North

open access: yesResources
The effects of climate change, such as melting ice and permafrost in northern and Arctic regions, raise serious concerns about the risk of accidents at oil production, transportation, and storage facilities.
Marina Nevskaya   +4 more
doaj   +1 more source

Knowledge, behaviour change, and anticipated compliance regarding non-pharmaceutical interventions during pandemic of influenza A H1N1 in Delhi

open access: yesLung India, 2012
Context : Compliance for non-pharmaceutical interventions for containment of Influenza A H1N1 is determined by community understanding and accurate information by appropriate risk commu-nication strategy.
Rinku Sharma, Suminder Kaur, Alka Sodhi
doaj   +1 more source

Validating the backtests of risk measures

open access: yes, 2007
Paper presented at INFINITI Conference on International Finance 11-12 June 2007, Trinity College Dublin. Also presented at Financial Management Association Annual Meeting, Orlando, Florida , 18-20 October 2007Financial risk model evaluation or ...
Cotter, John, Zhong, Yan Ping
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Evaluating the Precision of Estimators of Quantile-Based Risk Measures [PDF]

open access: yes
This paper examines the intra-day seasonality of transacted limit and market orders in the DEM/USD foreign exchange market. Empirical analysis of completed transactions data based on the Dealing 2000-2 electronic inter-dealer broking system indicates ...
Kevin Dowd, John Cotter
core  

Statistical methods for investment risk management.

open access: yes, 2023
The thesis presents two statistical approaches to risk management when investing in stocks: Modern Portfolio Theory and Conditional Value at Risk optimization, which is selected as an alternative for Value at Risk optimization. The thesis consists of two
Lebedevaitė, Vaida,
core  

Return Based Risk Measures for Non-Normally Distributed Returns: An Alternative Modelling Approach

open access: yes, 2021
Developments in the world of finance have led the authors to assess the adequacy of using the normal distribution assumptions alone in measuring risk. Cushioning against risk has always created a plethora of complexities and challenges; hence, this paper
Samunderu, Eyden   +3 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

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