Results 101 to 110 of about 8,450,169 (300)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Confronting LHC data with the statistical hadronization model

, 2013
The most recent data from the CERN LHC are compared with calculations within the statistical hadronization model. The parameters temperature und baryon chemical potential are fitted to the data.
Andronic, A, Braun-Munzinger, P, Redlich, K, Stachel, J   +3 more
core   +1 more source

A consideração da estrutura das unidades em inferências derivadas do experimento The consideration of the unit structure in inferences from the experiment

Pesquisa Agropecuária Brasileira, 1999
O modelo estatístico deve exprimir corretamente a estrutura do experimento. Isso é necessário para garantir que os componentes de variância que afetam efeitos referentes a fatores experimentais sejam idênticos aos componentes de variância usados para ...
João Gilberto Corrêa da Silva
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Statistical Model of Abstention under Compulsory Voting [PDF]

, 2011
Invalid voting and electoral absenteeism are two important sources of abstention in compulsory voting systems. Previous studies in this area have not considered the correlation between both variables and ignored the compositional nature of the data ...
Katz, Gabriel
core  

Statistical mechanics of the random K-SAT model

, 1997
The Random K-Satisfiability Problem, consisting in verifying the existence of an assignment of N Boolean variables that satisfy a set of M=alpha N random logical clauses containing K variables each, is studied using the replica symmetric framework of ...
A. Goerdt, A. Kamath, B. Aspvall, B. Selman, C. De Dominicis, C. De Dominicis, C. De Dominicis, C. De Dominicis, E. Gardner, G. Baskaran, G. Parisi, H. Orland, I. Kanter, J. A. Hertz, K.Y.M. Wong, L. Viana, M. Mezard, M. Mézard, M. Mézard, M.J. de Oliveira, O. Dubois, R. Monasson, R. Monasson, Riccardo Zecchina, Rémi Monasson, S. Katsura, S. Kirkpatrick, S. Kirkpatrick, S.A. Cook, T. R. Kirkpatrick, W. Krauth   +30 more
core   +1 more source

The example of BTJE flow path contamination assessment with anti-icing fluid using statistical models

Научный вестник МГТУ ГА
Contamination of the compressor flow path is one of the most prevalent issues encountered during the operation of aircraft gas turbine engines (GTEs). During operation in winter, ingestion of anti-icing fluids and de-icing agents into the compressor flow
S. V. Nekrasov, B. A. Chichkov
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The QCD Phase Diagram from Statistical Model Analysis

, 2017
Ideally, the Statistical Hadronization Model (SHM) freeze-out curve should reveal the QCD parton-hadron phase transformation line in the ($T$,$\mu_B$) plane.
Becattini, Francesco, Bleicher, Marcus, Steinheimer, Jan, Stock, Reinhard   +3 more
core   +2 more sources