Results 121 to 130 of about 3,722,372 (219)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

A Statistical Model to Estimate the Potential Risk of Work-Related Stroke among Office Workers: A Methodological Description Article. [PDF]

Iran J Public Health
Farghadan M, Almutairi NS, Shariat A, Anastasio AT.   +3 more
europepmc   +1 more source

CoRegNet: unraveling gene co-regulation networks from public RNA-Seq repositories using a beta-binomial statistical model. [PDF]

Brief Bioinform, 2023
Wang J, Wan YW, Al-Ouran R, Huang M, Liu Z.   +4 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A statistical model to determine the optimal bone mineral density (BMD) screening schedule in liver transplant recipients. [PDF]

J Liver Transpl
Koyya HR, Meredith E, Gharehmohammadi F, Elmahdy M, Sebro R.   +4 more
europepmc   +1 more source

Data analysis for COVID-19 deaths using a novel statistical model: Simulation and fuzzy application. [PDF]

PLoS One, 2023
El-Sherpieny EA, Almetwally EM, Muse AH, Hussam E.   +3 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Statistical Model of Ocular Wavefronts With Accommodation. [PDF]

Invest Ophthalmol Vis Sci
Mechó-García M, Arcas-Carbonell M, Orduna-Hospital E, Sánchez-Cano A, López-Gil N, Macedo-de-Araújo RJ, Faria-Ribeiro M, Fernandes P, González-Méijome JM, Rozema J.   +9 more
europepmc   +1 more source

Statistical model of trajectories of reduced mobility in older people with locomotive disorders: a prospective cohort study with group-based trajectory model. [PDF]

BMC Geriatr, 2023
Iwaya T, Tanabe H, Ohkuma Y, Ito A, Hayashi K, Ideno Y, Nagai K, Akai M.   +7 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source