Results 141 to 150 of about 3,722,372 (219)

Difficult-to-treat psoriatic arthritis: refining the definition using a statistical model in a real-life cohort. [PDF]

Front Med (Lausanne)
Favalli EG, Biganzoli G, Cincinelli G, Ferrito M, Luconi E, Manara M, Biggioggero M, Boracchi P, Caporali R.   +8 more
europepmc   +1 more source

Probiotic responder identification in cross-over trials for constipation using a Bayesian statistical model considering lags between intake and effect periods. [PDF]

Comput Struct Biotechnol J, 2023
Hosoda S, Nishimoto Y, Yamauchi Y, Yamada T, Hamada M.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A statistical model to identify hereditary and epigenetic fusion genes associated with dilated cardiomyopathy. [PDF]

Front Genet
Fei L, Zhang J, Zhuo D.
europepmc   +1 more source

Growth patterns and shape development of the paediatric mandible - A 3D statistical model. [PDF]

Bone Rep, 2022
O' Sullivan E, van de Lande LS, El Ghoul K, Koudstaal MJ, Schievano S, Khonsari RH, Dunaway DJ, Zafeiriou S.   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Relationship between Household Tuberculosis and Socioeconomic and Bioenvironmental Factors: A Statistical Model Approach Using NFHS-5 Data. [PDF]

Indian J Community Med
Pandey AK, Chaturvedi HK, Choraria P.
europepmc   +1 more source

Subgrain Coalescence Simulation by Means of an Advanced Statistical Model of Inelastic Deformation. [PDF]

Materials (Basel), 2022
Kondratev N, Trusov P, Podsedertsev A, Baldin M.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Statistical Model to Predict Protection Against Infant Respiratory Syncytial Virus Disease Through Maternal Immunization. [PDF]

Vaccines (Basel)
Cai B, Chen Y, Agosti Y, Schmoele-Thoma B, Koury K, Jansen KU, Gruber WC, Dormitzer PR, Swanson KA.   +8 more
europepmc   +1 more source