Results 161 to 170 of about 3,748,956 (269)

scDETECT: a novel statistical model accounting for cell type correlation in single-cell RNA-seq differential expression analysis. [PDF]

Brief Bioinform
Xu Y, Zhang W, Wu H.
europepmc   +1 more source

Correction: Foraging as sampling without replacement: A Bayesian statistical model for estimating biases in target selection. [PDF]

PLoS Comput Biol, 2023
Clarke ADF, Hunt AR, Hughes AE.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

STANCE: a unified statistical model to detect cell-type-specific spatially variable genes in spatial transcriptomics. [PDF]

Nat Commun
Su H, Wu Y, Chen B, Cui Y.
europepmc   +1 more source

eSMC: a statistical model to infer admixture events from individual genomics data. [PDF]

BMC Genomics, 2022
Wang Y, Zhao Z, Miao X, Wang Y, Qian X, Chen L, Wang C, Li S.   +7 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Difficult-to-treat psoriatic arthritis: refining the definition using a statistical model in a real-life cohort. [PDF]

Front Med (Lausanne)
Favalli EG, Biganzoli G, Cincinelli G, Ferrito M, Luconi E, Manara M, Biggioggero M, Boracchi P, Caporali R.   +8 more
europepmc   +1 more source

Growth patterns and shape development of the paediatric mandible - A 3D statistical model. [PDF]

Bone Rep, 2022
O' Sullivan E, van de Lande LS, El Ghoul K, Koudstaal MJ, Schievano S, Khonsari RH, Dunaway DJ, Zafeiriou S.   +7 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source