Results 181 to 190 of about 8,450,169 (300)

eSMC: a statistical model to infer admixture events from individual genomics data. [PDF]

BMC Genomics, 2022
Wang Y, Zhao Z, Miao X, Wang Y, Qian X, Chen L, Wang C, Li S.   +7 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

STANCE: a unified statistical model to detect cell-type-specific spatially variable genes in spatial transcriptomics. [PDF]

Nat Commun
Su H, Wu Y, Chen B, Cui Y.
europepmc   +1 more source

Probiotic responder identification in cross-over trials for constipation using a Bayesian statistical model considering lags between intake and effect periods. [PDF]

Comput Struct Biotechnol J, 2023
Hosoda S, Nishimoto Y, Yamauchi Y, Yamada T, Hamada M.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Difficult-to-treat psoriatic arthritis: refining the definition using a statistical model in a real-life cohort. [PDF]

Front Med (Lausanne)
Favalli EG, Biganzoli G, Cincinelli G, Ferrito M, Luconi E, Manara M, Biggioggero M, Boracchi P, Caporali R.   +8 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

A statistical model to identify hereditary and epigenetic fusion genes associated with dilated cardiomyopathy. [PDF]

Front Genet
Fei L, Zhang J, Zhuo D.
europepmc   +1 more source

Growth patterns and shape development of the paediatric mandible - A 3D statistical model. [PDF]

Bone Rep, 2022
O' Sullivan E, van de Lande LS, El Ghoul K, Koudstaal MJ, Schievano S, Khonsari RH, Dunaway DJ, Zafeiriou S.   +7 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source