Results 171 to 180 of about 8,450,169 (300)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Statistical Model of Ocular Wavefronts With Accommodation. [PDF]

Invest Ophthalmol Vis Sci
Mechó-García M, Arcas-Carbonell M, Orduna-Hospital E, Sánchez-Cano A, López-Gil N, Macedo-de-Araújo RJ, Faria-Ribeiro M, Fernandes P, González-Méijome JM, Rozema J.   +9 more
europepmc   +1 more source

Data analysis for COVID-19 deaths using a novel statistical model: Simulation and fuzzy application. [PDF]

PLoS One, 2023
El-Sherpieny EA, Almetwally EM, Muse AH, Hussam E.   +3 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

scDETECT: a novel statistical model accounting for cell type correlation in single-cell RNA-seq differential expression analysis. [PDF]

Brief Bioinform
Xu Y, Zhang W, Wu H.
europepmc   +1 more source

Validation of depression determinants in caregivers of dementia patients with machine learning algorithms and statistical model. [PDF]

Front Med (Lausanne), 2023
Cho K, Choi J, Han S.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Independent verification system for intracavitary brachytherapy based on a reference plan and statistical model. [PDF]

J Radiat Res
Akino Y, Isohashi F, Arimura T, Inoue S, Shiomi H, Hayashi K, Tatekawa S, Tamari K, Hirata T, Nakai M, Shimizu S, Ogawa K.   +11 more
europepmc   +1 more source

Correction: Foraging as sampling without replacement: A Bayesian statistical model for estimating biases in target selection. [PDF]

PLoS Comput Biol, 2023
Clarke ADF, Hunt AR, Hughes AE.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source