Results 71 to 80 of about 775,359 (318)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Statistical Model Checking of NetLogo model

CoRR
Agent-based models (ABMs) are gaining increasing traction in several domains, due to their ability to represent complex systems that are not easily expressible with classical mathematical models. This expressivity and richness come at a cost: ABMs can typically be analyzed only through simulation, making their analysis challenging.
Pangallo, Marco, Giachini, Daniele, Vandin, Andrea   +2 more
openaire   +3 more sources

Basic Ideas to Approach Metastability in Probabilistic Cellular Automata [PDF]

, 2018
Cellular Automata are discrete-time dynamical systems on a spatially extended discrete space, which provide paradigmatic examples of nonlinear phenomena.
Cirillo, E.M.N., Emilio N. M. Cirillo, Nardi, F.R., Mathematical Modeling, Francesca R. Nardi, Spitoni, C., Cristian Spitoni, Sub Mathematical Modeling   +7 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An Algorithm for Creating a Synaptic Cleft Digital Phantom Suitable for Further Numerical Modeling

Algorithms
One of the most significant applications of mathematical numerical methods in biology is the theoretical description of the convectional reaction–diffusion of chemical compounds.
Olga A. Zagubnaya, Yaroslav R. Nartsissov   +1 more
doaj   +1 more source

Towards Intelligent Modeling: Statistical Approximation Theory [PDF]

, 2011
The main idea of statistical convergence is to demand convergence only for a majority of elements of a sequence. This method of convergence has been investigated in many fundamental areas of mathematics such as: measure theory, approximation theory ...
Duman, Oktay, Oktay Duman, Anastassiou, George A., George A. Anastassiou, Anastassiou, George A   +4 more
core   +1 more source

A Generalization of Reciprocal Exponential Model: Clayton Copula, Statistical Properties and Modeling Skewed and Symmetric Real Data Sets: A Generalization of Reciprocal Exponential Model [PDF]

, 2020
We introduce a new extension of the reciprocal Exponential distribution for modeling the extreme values. We used the Morgenstern family and the clayton copula for deriving many bivariate and multivariate extensions of the new model.
Ansari, S. I., Butt, Nadeem Shafique, Mansour, M. M., Yousof, Haitham, Ibrahim, Mohamed   +4 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Tropical geometry of statistical models [PDF]

Proceedings of the National Academy of Sciences, 2004
This article presents a unified mathematical framework for inference in graphical models, building on the observation that graphical models are algebraic varieties. From this geometric viewpoint, observations generated from a model are coordinates of a point in the variety, and the sum-product algorithm is an efficient tool for evaluating specific ...
Pachter, Lior, Sturmfels, Bernd
openaire   +6 more sources