Results 61 to 70 of about 2,959,577 (269)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Hybrids of Gibbs Point Process Models and Their Implementation [PDF]

, 2013
We describe a simple way to construct new statistical models for spatial point pattern data. Taking two or more existing models (finite Gibbs spatial point processes) we multiply the probability densities together and renormalise to obtain a new ...
Adrian Baddeley, Bevan, A., Bevan, A, Baddeley, Adrian, Bevan, Andrew, Rolf Turner, Mateu, J, Turner, R, Mateu, J., Baddeley, A, Jorge Mateu, Mateu, Jorge, Turner, Rolf, Turner, R., Andrew Bevan   +14 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Forecasting Electric Load Demand through Advanced Statistical Techniques

, 2020
Traditional forecasting models have been widely used for decision-making in production, finance and energy. Such is the case of the ARIMA models, developed in the 1970s by George Box and Gwilym Jenkins [1], which incorporate characteristics of the past ...
Colombia, Bayesian methods, Decision making, Electric load forecasting, Electric load demands, Bayesian networks, Statistical techniques, Forecasting models   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

From p+p to Pb+Pb collisions : wounded nucleon versus statistical models

, 2013
System size dependence of hadron production properties is discussed within the Wounded Nucleon Model and the Statistical Model in the grand canonical, canonical and micro-canonical formulations.
Marek Gazdzicki, Gaździcki, Marek
core   +1 more source

Statistical Inference in Calibrated Models [PDF]

Journal of Applied Econometrics, 1994
SUMMARY This paper describes a Monte Carlo procedure to assess the performance of calibrated dynamic general equilibrium models. The procedure formalizes the choice of parameters and the evaluation of the model and provides an efficient way to conduct a sensitivity analysis for perturbations of the parameters within a reasonable range.
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

SHAPE - Statistical Models For Human Perception And Evaluation

, 2014
The main aim of the Scientific project was to unify several approaches for modelling ordinal data by exploiting disseminated competences on alternative methodologies and performing an international experience on well documented data sets of real ...
M. Iannario
core