Results 81 to 90 of about 6,283,547 (291)

Complexities of student dropout in higher education: a multidimensional analysis

Frontiers in Education
IntroductionStudent dropout, as a dynamic and complex system, requires a broad conceptualization. The aim of this article is to analyze the concept of student dropout in higher education, with the aim of effectively addressing it at various levels ...
Sandra Patricia Barragán Moreno, Leandro González Támara   +1 more
doaj   +1 more source

Scaling of local interface width of statistical growth models

, 2004
We discuss the methods to calculate the roughness exponent alpha and the dynamic exponent z from the scaling properties of the local roughness, which is frequently used in the analysis of experimental data.
Aarão Reis, Anna Chame, Baggio, Barabási, Buceta, Chatraphorn, Costa, Das Sarma, Das Sarma, Das Sarma, Das Sarma, Edwards, F.D.A. Aarão Reis, Family, Forrest, Horowitz, Huang, Kardar, Kim, Kotrla, Kotrla, Krim, Krug, Lai, Leschhorn, López, Majaniemi, Park, Plischke, Predota, Punyindu, Rao, Ryu, Siegert, Smilauer, Villain, Vvedensky, Wolf   +37 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Flowering prediction of pear tree (Pyrus communis L.), apple tree (Malus domestica Borkh) and plum tree (Prunus domestica L.) - similarities and differences

Acta Agriculturae Slovenica, 2001
Paper discusses the similarities and differences in predicting the full flowering of apple tree (cv. 'Bobovec'), pear tree (cv. 'Pastorjevka') and domestic plum tree. The study was conducted at University of Ljubljana.
Klemen BERGANT, Zalika ČREPINŠEK, Lučka KAJFEŽ-BOGATAJ   +2 more
doaj   +1 more source

Thomas-Fermi Statistical Models of Finite Quark Matter

, 2009
I introduce and discuss models of finite quark matter using the formalism of the Thomas-Fermi statistical model. Similar to bag models, a vacuum energy term is introduced to model long distance confinement, but the model produces bound states from the ...
Abbasi, Alford, Alford, Alford, Alford, Alford, Berger, Choi, Dixon, Dixon, Farhi, Fermi, Kiriyama, Kiriyama, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Madsen, Monreal, Nakano, Rajagopal, Rajagopal, Sikivie, Spence, Spruch, Thomas, Walter Wilcox, Weber, Witten   +32 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source