Results 91 to 100 of about 6,283,547 (291)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evaluating the forecasting performance of ensemble sub-epidemic frameworks and other time series models for the 2022–2023 mpox epidemic

Royal Society Open Science
During the 2022–2023 unprecedented mpox epidemic, near real-time short-term forecasts of the epidemic’s trajectory were essential in intervention implementation and guiding policy.
Amanda Bleichrodt, Ruiyan Luo, Alexander Kirpich, Gerardo Chowell   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Forecasting Plastic Waste Fractions: A Recycling Perspective

Proceedings of the Conference on Production Systems and Logistics
Data has huge potential for optimizing the performance of sorting and processing plants in the recycling sector. Improved quality of recyclates increases the number of cycles secondary materials stay in the loop, contributing to the vision of circular ...
Becker, Jakob, Kempkes, Philipp, Mielke, Konrad, Fendel, Ansgar, Bommert, Andrea, Pauly, Markus, Herberger, David, Hübner, Marco   +7 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Race/Ethnic differences and age-variation in the effects of birth outcomes on infant mortality in the U.S.

Demographic Research, 2006
This paper investigates the effects of birth outcomes on infant mortality for non-Hispanic white, black, and Mexican-American females in the U.S. (1995-1998).
Patricio Solis, Starling G. Pullum, Robert A. Hummer, W. Parker Frisbie, Daniel A. Powers   +4 more
doaj  

Signs of Slowing Recovery of Antarctic Ozone Hole in Recent Late Winter–Early Spring Seasons (2020–2023)

Atmosphere
Every year since the early 1980s, the ozone hole has appeared in late winter/spring over Antarctica. The ozone hole is expected to disappear due to the observed decrease in the concentration of ozone-depleting substances in the stratosphere, which is ...
Janusz Krzyścin, Agnieszka Czerwińska
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Development of an Indonesian Trade Forecasting Information System Based on Statistical Models and Gradient Boosting

Jurnal Sisfokom
Current Indonesian trade forecasting relies on complex manual processes prone to inaccuracies. This study develops an Indonesian Trade Forecasting Information System integrating Statistical Models (SARIMA, Prophet) and Gradient Boosting (LightGBM ...
Muh. Ashari Rasyid, Nouval Trezandy Lapatta   +1 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source