Results 91 to 100 of about 2,959,577 (269)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Probabilistic and statistical models for conception
, 2010 Statistical models of fertility studies play a crucial role in understanding the biology of conception. Heterogeneity in women and men's requires specific statistical methods to be used in order to allow for the variability in behavioral and physical ...
SCARPA, BRUNO, Bruno Scarpa
core +1 more source
Canonical foliations of statistical manifolds with statistical models
Information GeometryAbstract Constructing a realisation of a statistical manifold as a statistical model, i.e a manifold with dual connections with respect to a Fisher metric, is an important question in information geometry. While a positive answer to this problem was given by the work on Hong Van Lé [1], writing explicitly the ...
Gnandi, Emmanuel +2 more
openaire +1 more source
The statistical model for parton distributions
, 2012 7 pages, 3 figures, Invited talk at XX International Workshop on "`Deep-Inelastic Scattering and related subjects"', University of Bonn, Germany, March 26-30 2012, presented by F.
Bourrely, Claude +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Spatial statistical models that use flow and stream distance
, 2006 We develop spatial statistical models for stream networks that can estimate relationships between a response variable and other covariates, make predictions at unsampled locations, and predict an average or total for a stream or a stream segment.
Theobald, David +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Statistical validation of simulation models: A case study
Rigorous statistical validation requires that the responses of the model and the real system have the same expected values. However, the modeled and actual responses are not comparable if they are obtained under different scenarios (environmental ...
Kleijnen, J.P.C.
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source