Results 71 to 80 of about 11,330,431 (362)
BMC Medical Research Methodology, 2019 BackgroundDespite its popularity, issues concerning the estimation of power in multilevel logistic regression models are prevalent because of the complexity involved in its calculation (i.e., computer-simulation-based approaches).
Oscar L. Olvera Astivia +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Sample size and its importance in research
Indian Journal of Psychological Medicine, 2020 The sample size for a study needs to be estimated at the time the study is proposed; too large a sample is unnecessary and unethical, and too small a sample is unscientific and also unethical.
Chittaranjan Andrade
doaj +1 more source
Tailor-made tests for goodness of fit to semiparametric hypotheses [PDF]
Annals of Statistics 2006, Vol. 34, No. 2, 721-741, 2006 We introduce a new framework for constructing tests of general semiparametric hypotheses which have nontrivial power on the $n^{-1/2}$ scale in every direction, and can be tailored to put substantial power on alternatives of importance. The approach is based on combining test statistics based on stochastic processes of score statistics with bootstrap ...
arxiv +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
A Systematic Review on the Evolution of Power Analysis Practices in Psychological Research
Psychologica BelgicaPerforming hypothesis tests with adequate statistical power is indispensable for psychological research. In response to several large-scale replication projects following the replication crisis, concerns about the root causes of this crisis – such as ...
Lara Vankelecom +4 more
doaj +1 more source
The relation between statistical power and inference in fMRI
PLoS ONE, 2017 Statistically underpowered studies can result in experimental failure even when all other experimental considerations have been addressed impeccably.
H. Cremers, T. Wager, T. Yarkoni
semanticscholar +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source