Results 71 to 80 of about 4,058,415 (318)

Normrank Correlations for Testing Associations and for Use in Latent Variable Models

open access: yesOpen Education Studies
Pearson’s correlation is widely used to test for an association between two variables and also forms the basis of several multivariate statistical procedures including many latent variable models. Spearman’s ρ\rho is a popular alternative.
Wright Daniel B.
doaj   +1 more source

Provable Sparse Tensor Decomposition

open access: yes, 2016
We propose a novel sparse tensor decomposition method, namely Tensor Truncated Power (TTP) method, that incorporates variable selection into the estimation of decomposition components. The sparsity is achieved via an efficient truncation step embedded in
Cheng, Guang   +3 more
core   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

A Review of Sample Size Determination for Common Experi-mental Designs: Further Simplified Equations [PDF]

open access: yesمجلة جامعة النجاح للأبحاث العلوم الطبيعية
Determination of the required sample size is an important step in the planning of any research study. A large number of commercial and online resources are readily available for calculation of sample size required for various research designs.
Jihad M. Abdallah
doaj   +1 more source

Macroscopic thermodynamics of equilibrium characterized by power-law canonical distributions

open access: yes, 2000
Macroscopic thermodynamics of equilibrium is constructed for systems obeying power-law canonical distributions. With this, the connection between macroscopic thermodynamics and microscopic statistical thermodynamics is generalized.
A. K Rajagopal   +8 more
core   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Theory and practice of clinical trials in oncology and hematology

open access: yesОнкогематология, 2016
In the era of evidence-based medicine the main reason for the implementation of new treatment methods are the results of clinical trials. However, clinical trials is a separate area of knowledge, which is often little known to clinicians, that does not ...
N. V. Zhukov
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Self-organization of structures and networks from merging and small-scale fluctuations

open access: yes, 2004
We discuss merging-and-creation as a self-organizing process for scale-free topologies in networks. Three power-law classes characterized by the power-law exponents 3/2, 2 and 5/2 are identified and the process is generalized to networks.
A Trusina   +18 more
core   +2 more sources

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