Results 81 to 90 of about 15,562,972 (297)
A Comparison of Shiryaev–Roberts and Cumulative Sum Procedures for Bivariate ZIP Process Monitoring
AxiomsThe Zero-inflated Poisson (ZIP) model has been widely adopted in quality control for near-zero-defect processes with sporadic nonconformities, while prior research predominantly focused on univariate ZIP processes for single defect types, modern high ...
Xiaoling Bo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Performance monitoring of MPC based on dynamic principal component analysis
, 2011 A unified framework based on the dynamic principal component analysis (PCA) is proposed for performance monitoring of constrained multi-variable model predictive control (MPC) systems.
Chen, Sheng +3 more
core +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MathematicsThe change-point model is an established methodology for the construction of self-starting control charts. Change-point charts are often nonparametric in order to be independent from any specific assumptions about the process distribution.
Claudio Giovanni Borroni +2 more
doaj +1 more source
Quality Weakly Related Fault Detection Based on Weighted Dual-Step Feature Extraction
IEEE Access, 2019 Process variables can be separated into quality strongly related variables (QSRVs) and quality weakly related variables (QWRVs) based on the difference of correlation between process variables and quality.
Bo Zhao +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MathematicsThis study proposes the Quadruple Exponentially Weighted Moving Average (QEWMA) control chart, a novel monitoring scheme designed to enhance the detection of small-to-moderate process mean shifts in the presence of autocorrelation. While traditional EWMA-
Julalak Neammai +2 more
doaj +1 more source