Results 101 to 110 of about 5,852,793 (269)

Common pitfalls in statistical analysis: The perils of multiple testing

Perspectives in Clinical Research, 2016
Multiple testing refers to situations where a dataset is subjected to statistical testing multiple times - either at multiple time-points or through multiple subgroups or for multiple end-points. This amplifies the probability of a false-positive finding.
Priya Ranganathan, C S Pramesh, Marc Buyse   +2 more
doaj   +1 more source

The vector floor and ceiling model [PDF]

, 2006
This paper motivates and develops a nonlinear extension of the Vector Autoregressive model which we call the Vector Floor and Ceiling model. Bayesian and classical methods for estimation and testing are developed and compared in the context of an ...
Koop, Gary, Potter, Simon
core  

Angular Baryon Acoustic Oscillation measure at z=2.225 from the SDSS quasar survey

, 2018
Following a quasi model-independent approach we measure the transversal BAO mode at high redshift using the two-point angular correlation function (2PACF).
Bernui, A., Carvalho, G. C., de Carvalho, E., Novaes, C. P., Xavier, H. S.   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Two enological titans rate the 2009 Bordeaux wines

Wine Economics and Policy, 2014
The purpose of this research was to compare the ratings of 237 2009 Bordeaux wines by Jancis Robinson (JR) and Robert Parker (RP). Results indicate that the level of agreement was 81.77% as compared to an expected agreement of 80.92%.
Dom Cicchetti, Arnie Cicchetti
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

I know what I shouldn’t say, but what should I say? An approach to present results without statistical significance

Frontiers in Applied Mathematics and Statistics
There has been an important move away from the term “statistical significance” in the scientific and statistical community. The desire to “retire 0.05” is rooted in improving scientific reporting by ensuring that researchers report more information than ...
Brian C. Healy, Brian C. Healy, Brian C. Healy   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Using Dichotomous Variables to Model Structural Changes in Time Series: An Application to International Trade

Engineering Proceedings
This research aimed to elucidate the methodology employed in econometric estimations by utilizing dichotomous variables. These variables served a dual purpose: firstly, they denoted an attribute designed to discern structural changes within a linear ...
Gerardo Covarrubias, Xuedong Liu
doaj   +1 more source