Results 121 to 130 of about 5,906,609 (291)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Reply to "The statistical significance may be misinterpreted". [PDF]

J Chin Med Assoc, 2023
Cheng YW, Chen YY, Lin CJ, Chen YT, Lieu AS, Tsai HP, Kwan AL.   +6 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Series 1: Integrating Medical Research Into Clinical Reasoning: Exploring Bayesian Analysis as a Complement to Traditional Statistics [PDF]

Perspectives In Medical Research
Sayed Kashif Momin
doaj   +1 more source

Small Samples, Big Problems, Statistical Tests in Nematology Research Need Power

Journal of Nematology
In nematology research, hypothesis testing is a fundamental method and is typically supported by statistical significance (e.g., P-value
Ko Itsuhiro, Rice David
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Reporting and interpreting statistical results in veterinary medicine: Calling for change

Journal of Veterinary Internal Medicine
Understanding and correctly interpreting statistical results presented in scientific articles is a required skill for practicing evidence‐based veterinary medicine.
Hsin‐Yi Weng, Locksley L. McV. Messam
doaj   +1 more source

On p-Values and Statistical Significance. [PDF]

J Clin Med, 2023
Bonovas S, Piovani D.
europepmc   +1 more source

AGRICULTURAL ECONOMISTS' EFFECTIVENESS IN REPORTING AND CONVEYING RESEARCH PROCEDURES AND RESULTS [PDF]

This study reviews articles using regression analysis published in the Journal of Agricultural and Resource Economics from 1994 to 1998 to determine agricultural economists' effectiveness in reporting and conveying research procedures and results.
Dhuyvetter, Kevin C., Kastens, Terry L., Parcell, Joseph L., Schroeder, Ted C.   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source