Results 141 to 150 of about 3,130,781 (258)

Variation across analysts in statistical significance, yet consistently small effect sizes. [PDF]

Proc Natl Acad Sci U S A, 2023
Mathur MB, Covington C, VanderWeele TJ.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Survival-inferred fragility of statistical significance in phase III oncology trials. [PDF]

NPJ Precis Oncol
Sherry AD, Liu Y, Msaouel P, Lin TA, Koong A, Lin C, Abi Jaoude J, Patel RR, Kouzy R, El-Alam MB, Miller AM, Owiwi M, Ofer J, Bomze D, McCaw ZR, Meirson T, Ludmir EB.   +16 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

About Research: Clinical Versus Statistical Significance. [PDF]

J Hum Lact
Wouk K, Kenny K, Chetwynd E.
europepmc   +1 more source

Replacing statistical significance and non-significance with better approaches to sampling uncertainty. [PDF]

Front Physiol, 2022
Hopkins WG.
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Disparity between statistical significance and clinical importance in published randomised controlled trials: a methodological study. [PDF]

BMJ Open
Esterhuizen TM, Mbuagbaw L, Rehman N, Yanwou N, Swaby DJ, Kittle E, Licht JC, Thabane L.   +7 more
europepmc   +1 more source

Is it time to stop using statistical significance? [PDF]

Aust Prescr, 2021
Frank O, Tam CM, Rhee J.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source